Increasing Prevalence Rate of Nontuberculous Mycobacteria Infections in Five States, 2008-2013
Increasing Prevalence Rate of Nontuberculous Mycobacteria Infections in Five States, 2008-2013
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DOI：
10.1513/annalsats.201605-353oc
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发表时间：
2016-12-01
影响因子：
8.3
通讯作者：
Wymer, Larry
中科院分区：
文献类型：
--
作者：
Donohue, Maura J.;Wymer, Larry
理由：许多非结核分枝杆菌（NTM）是临床上重要的病原体，可在多种不同的人体器官和组织中引起疾病。目的：进行了一项基于人群的研究，以调查美国五个州NTM阳性标本患者的患病率。方法：我们使用2008年至2013年间提交给五个州（马里兰州、密西西比州、密苏里州、俄亥俄州和威斯康星州）疾病监测系统的数据，确定了至少有一个标本呈NTM阳性的患者的病例和年龄分布。计算了每个州每10万人的粗患病率、特定年龄患病率和年龄调整患病率。测量结果和主要结果：2008 - 2013年，5个州共向疾病监测系统报告了24226例NTM病例。在监测期开始和结束期间，总体年平均年龄调整患病率从每10万人8.7人上升到13.9人。50 ~ 80岁以上年龄组的病例数和发病率高于0 ~ 49岁年龄组。按年龄分类的患病率在五个州有所不同。在密西西比州80岁以上年龄组中观察到的NTM病例数量最多，而威斯康星州在60至69岁年龄组中观察到的NTM病例数量最多。结论：2008 - 2013年NTM阳性标本呈上升趋势。随着美国人口的老龄化，这一趋势很可能在未来十年继续下去。为了减少NTM感染的流行，需要为易感人群提供医疗指导，说明如果要减轻疾病负担，可以采取哪些行动来避免接触NTM的来源和途径。
Rationale: Many nontuberculous mycobacteria (NTM) are clinically significant pathogens that cause disease in a variety of different human organs and tissues.Objectives: A population-based study was undertaken to investigate the prevalence of patients with a positive specimen for NTM within five states of the United States.Methods: We determined the case and age distribution of patients with at least one specimen positive for NTM, using data submitted to the disease surveillance systems of five states (Maryland, Mississippi, Missouri, Ohio, and Wisconsin) between 2008 and 2013. Crude, age-specific, and age-adjusted prevalence rates per 100,000 persons were calculated for each state.Measurements and Main Results: From 2008 to 2013, a total of 24,226 NTM cases were reported to the disease surveillance systems of the five states. The overall average annual age-adjusted prevalence rate rose from 8.7 to 13.9 per 100,000 persons between the beginning and end of the surveillance period. The number of cases and case rate in the 50-80+-year age group was higher than in the 0-49-year age group. Prevalence by age category differed among the five states. The highest number of NTM cases was observed in Mississippi for the 80+-year age group, whereas Wisconsin observed the highest number of NTM cases in the 60- to 69-year age group.Conclusions: From 2008 to 2013, the number of patients with positive specimens for NTM rose. This trend is likely to continue in the coming decade as the U.S. population ages. To reduce the prevalence of NTM infections, medical guidance for susceptible populations is needed regarding actions that can be taken to avoid sources and routes of exposure to NTMs if the disease burden is to be reduced.