Social environments and the genetics of aging: Advancing knowledge of protective health mechanisms
Social environments and the genetics of aging: Advancing knowledge of protective health mechanisms
复制标题
DOI：
10.1093/geronb/60.special_issue_1.12
复制
发表时间：
2005-03-01
影响因子：
6.2
通讯作者：
Singer, BH
中科院分区：
文献类型：
--
作者：
Ryff, CD;Singer, BH
我们选择性地回顾了行为和分子遗传学方面的文献，包括实验室和流行病学研究，重点是社会环境。尤其是在重要的社会关系中的情感。影响基因表达。注意人类和动物研究之间的串扰。环境是理解表型结果的关键，这需要研究基因-环境相互作用。说明性的相互作用，涉及行为和分子遗传学。提供。许多具有多种疾病易感基因的人从未进入疾病状态。大量的相关证据表明，社会环境因素是保护剂。在某些动物种群中，对这些联系的机械理解是相当先进的，并提出了人类研究的新路线。开发遗传学之间的接口。社会环境和健康将需要精通分子生物学和生物化学的人与具有遗传流行病学和社会心理学专门知识的人密切合作。特别重要的是查明保护易受感染者不受疾病影响的环境影响。
We selectively review the literature in behavioral and molecular genetics, including both laboratory and epidemiologic studies, with emphasis on how social environments. particularly emotion in significant social relationships. influence gene expression. Attention is given to cross-talk between human and animal studies. Environments are pivotal in understanding phenotypic outcomes, and this demands research on gene-environment interactions. Illustrative interactions, involving both behavioral and molecular genetics. are provided. Many people with susceptibility genes for diverse diseases never proceed to disease status. Substantial associational evidence implicates social environmental factors as protective agents. Mechanistic understanding of these linkages is quite advanced in some animal populations and suggests new lines of inquiry in human studies. Developing the interface between genetics. social environments, and health will require close collaboration between those well versed in molecular biology and biochemistry and persons with expertise in genetic epidemiology and social psychology. Particularly important is the identification of environmental influences that protect susceptible persons from disease incidence.