Computer simulations of electrokinetic injection techniques in microfluidic devices
Computer simulations of electrokinetic injection techniques in microfluidic devices
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DOI：
10.1021/ac991474n
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发表时间：
2000-08-01
影响因子：
7.4
通讯作者：
Ramsey, JM
中科院分区：
文献类型：
--
作者：
Ermakov, SV;Jacobson, SC;Ramsey, JM
计算机模拟用于研究微流体装置（微芯片）上的电动注射。门控和捏注射技术被认为是。每种注入技术使用具有通道中不同电场分布和场大小的独特步骤序列来实现虚拟阀。这些计算机模拟的目的是确定提供最佳阀门性能的操作参数。在夹捏进样中，分析了加载和分配步骤的条件，以在样品塞空间范围和其浓度之间达成折衷。对于门控进样，发现样品加载步骤的无泄漏阀操作条件。对闸阀的模拟结果与实验数据进行了比较。
Computer simulations are used to study electrokinetic injections on microfluidic devices (microchips). The gated and pinched injection techniques are considered. Each injection technique uses a unique sequence of steps with different electric field distributions and field magnitudes irm the channels to effectuate a virtual valve. The goal of these computer simulations is to identify operating parameters providing optimal valve performance. In the pinched injection, the conditions of both loading and dispensing steps were analyzed to reach a compromise between the sample plug spatial extent and its concentration. For the gated injection, the condition of leakage free valve operation was found for the sample loading step. The simulation results for the gated valve are compared with experimental data.