Quantitative T2' imaging in patients with clinically isolated syndrome.
Quantitative T2' imaging in patients with clinically isolated syndrome.
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DOI：
10.1111/j.1600-0404.2011.01635.x
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发表时间：
2012-11
影响因子：
3.5
通讯作者：
Schippling S
中科院分区：
文献类型：
--
作者：
Reitz LY;Inglese M;Fiehler J;Finsterbusch J;Holst B;Heesen C;Martin R;Schippling S
T2′成像对复发缓解型多发性硬化（RRMS）患者正常外观白色和灰质（NAWM，NAGM）的氧饱和度变化敏感。我们的目的是探讨临床孤立综合征（CIS）患者T2′改变的存在和程度，以及T2′与常规MRI和临床结局的可能相关性。在32名首次接受治疗的CIS患者中采集了定量T2和T2* 加权图像，这些患者在发病3个月内出现CIS，15名年龄匹配的健康对照（HC）。在六个感兴趣区域（ROIs）中确定了定量T2 '值。CIS与HC的T2′值无显著性差异。患者中T2′值与T2病灶体积呈正相关（T2LV，r= 0.34，p <0.05）。额叶NAWM的T2′值与T2LV（r=0.35，p<0.05）和T2病变计数（r=0.4，p=0.02）相关。与RRMS相反，CIS患者与HC相比未显示T2′改变。然而，T2LV与较高T2′值之间的相关性表明，T2′反映了疾病的演变。在CIS中，代谢变化可能被代偿机制掩盖，并且当疾病进展时变得明显，如RRMS患者所示。
T2′ imaging has been shown to be sensitive to oxygen saturation changes in normal appearing white and grey matter (NAWM, NAGM) in patients with relapsing-remitting multiple sclerosis (RRMS). We aimed to explore the presence and extent of T2′ changes in patients with a clinically isolated syndrome (CIS) and a possible association of T2′ with conventional MRI and clinical outcomes. Quantitative T2- and T2*-weighted images were acquired in 32 treatment-naive patients with a CIS within 3 months of presentation and 15 age-matched healthy controls (HC). Quantitative T2′ values were determined in six regions of interest (ROIs). T2′ values in CIS did not differ significantly from those in HC. Among patients, T2′ values correlated positively with the T2 lesion volume (T2LV, r=0.34, p<0.05). T2′ values of the frontal NAWM correlated with the T2LV (r=0.35, p<0.05) and T2 lesion count (r=0.4, p=0.02). As opposed to RRMS, patients with CIS did not show T2′ alterations compared to HC. However, the association between the T2LV and higher T2′ values suggests that T2′ reflects disease evolution. In CIS metabolic changes might be masked by compensatory mechanisms and become overt when disease progresses as has been shown for RRMS patients.
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影响因子：
3.5
作者：
Burman, J.;Raininko, R.;Fagius, J.
通讯作者：
Fagius, J.
影响因子：
14.5
作者：
Fernando, KTM;McLean, MA;Miller, DH
通讯作者：
Miller, DH
影响因子：
6.4
作者：
Graumann, U;Reynolds, R;Schaeren-Wiemers, N
通讯作者：
Schaeren-Wiemers, N
影响因子：
9.9
作者：
Blinkenberg, M;Jensen, CV;Sorensen, PS
通讯作者：
Sorensen, PS
影响因子：
11
作者：
Henry, R. G.;Shieh, M.;Pelletier, D.
通讯作者：
Pelletier, D.