In vivo cell mediated immunity and vaccination response following prolonged, intense exercise
In vivo cell mediated immunity and vaccination response following prolonged, intense exercise
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DOI：
10.1097/00005768-199709000-00009
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发表时间：
1997-09-01
期刊：
影响因子：
--
通讯作者：
Pedersen, BK
中科院分区：
文献类型：
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作者：
Bruunsgaard, H;Hartkopp, A;Pedersen, BK
流行病学和实验研究表明，高强度、长时间运动后感染的频率和严重程度会增加。本研究旨在检验高强度、长时间运动后是否能证明体内细胞介导的免疫和抗体产生受到损害。22名男性铁人三项运动员完成了半程铁人三项比赛（A组）。运动后接种了破伤风和白喉类毒素以及纯化的肺炎球菌多糖疫苗。此外，在前臂进行了七种不同抗原的皮肤试验。在运动前和运动后2周测量抗体滴度。在接种后48小时读取皮肤试验结果。11名不运动的铁人三项运动员（B组）和22名适度训练的男性（C组）作为对照组。A组对破伤风抗原的皮肤试验反应明显低于B组和C组。A组的累积反应（硬结直径总和以及阳性皮肤试验点数）比B组和C组都小。三组之间抗体滴度没有差异。因此，长时间高强度运动后的最初几天体内细胞介导的免疫受到损害，而接种疫苗2周后测量的体内抗体产生没有受到损害。
Epidemiological and experimental studies have shown increased frequency and severity of infections after intense, long-term exercise. This study examines whether an in vivo impairment of the cell-mediated immunity and antibody production can he demonstrated after intense, long-term exercise. Twenty-two male triathletes performed one-half an ironman (group A). Vaccinations with tetanus and diphtheritis toroid and purified pneumococcal polysaccharide were given after the exercise. Furthermore, a skin test with seven different antigens was applied on the forearm. Antibody titers were measured before and 2 wk after the exercise. The skin test was read 48 h after the application. Eleven non-exercising triathletes (group B) and 22 moderately trained men (group C) were used as control groups. Group A revealed a significantly lower skin test response to the tetanus antigen than both groups B and C. In group A, a smaller cumulative response (sum of the diameters of indurations and number of positive skin test spots) was found than in both groups B and C. No differences in antibody titers were found among the three groups. Thus, the in vivo cell-mediated immunity was impaired in the first days after prolonged, high intensity exercise, whereas there was no impairment of the in vivo antibody production measured 2 wk after vaccination.