On the potential of a new IVUS elasticity modulus imaging approach for detecting vulnerable atherosclerotic coronary plaques: in vitro vessel phantom study.
On the potential of a new IVUS elasticity modulus imaging approach for detecting vulnerable atherosclerotic coronary plaques: in vitro vessel phantom study.
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DOI：
10.1088/0031-9155/55/19/006
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发表时间：
2010-10-07
影响因子：
3.5
通讯作者：
Ohayon J
中科院分区：
文献类型：
--
作者：
Le Floc'h S;Cloutier G;Finet G;Tracqui P;Pettigrew RI;Ohayon J
冠状动脉应力幅值峰值被认为是易损斑块（VP）破裂的良好指标。然而，这种应力评估强烈依赖于对斑块组分所表现出的机械性能的精确但仍然缺乏的了解。作为对这种限制的第一个反应，我们的小组最近在以前的理论研究中开发了一种称为iMOD的原始方法，该方法通过估计应变场来重建动脉粥样硬化斑块的弹性图（或模量图）。在目前对PVA-C动脉体模进行的体外实验研究中，我们研究了将iMOD程序与血管内超声（IVUS）测量值采集耦合以检测VP的受益。我们的研究结果表明，iMOD-IVUS组合策略：1）成功检测和量化软夹杂物轮廓，阳性预测值和灵敏度分别为89.7 ± 3.9%和81.5 ± 8.8%，2）合理估计帽厚度大于约300 µm，但低估了较薄的帽，（3）对硬介质的杨氏模量进行了满意的定量（平均值为109.7 ± 23.7 kPa，而非145.4 ± 31.8 kPa），但高估了软夹杂物的刚度（平均杨氏模量为31.4 ± 9.7 kPa，而不是17.6 ± 3.4 kPa）。总之，这些结果证明了新的iMOD-IVUS临床成像方法用于体内VP检测的有希望的益处。
Peak cap stress amplitude is recognized as a good indicator of vulnerable plaque (VP) rupture. However, such stress evaluation strongly relies on a precise, but still lacking, knowledge of the mechanical properties exhibited by the plaque components. As a first response to this limitation, our group recently developed, in a previous theoretical study, an original approach, called iMOD, which reconstructs elasticity maps (or modulograms) of atheroma plaques from the estimation of strain fields. In the present in vitro experimental study, conducted on PVA-C arterial phantoms, we investigate the benefit of coupling the iMOD procedure with the acquisition of intravascular ultrasound (IVUS) measurements for detection of VP. Our results show that the combined iMOD-IVUS strategy : 1) successfully detected and quantified soft inclusion contours with high positive predictive values and sensitivities of 89.7 ± 3.9% and 81.5 ± 8.8 %, respectively, 2) estimated reasonably cap thicknesses larger than ~300 µm, but underestimated thinner caps, and 3) quantified satisfactorily Young's modulus of hard medium (mean value of 109.7 ± 23.7 kPa instead of 145.4 ± 31.8 kPa), but overestimated the stiffness of soft inclusions (mean Young`s moduli of 31.4 ± 9.7 kPa instead of 17.6 ± 3.4 kPa). All together, these results demonstrate a promising benefit of the new iMOD-IVUS clinical imaging method for in vivo VP detection.