Interstitial tumour cell invasion in small hepatocellular carcinoma. Evaluation in microscopic and low magnification views
Interstitial tumour cell invasion in small hepatocellular carcinoma. Evaluation in microscopic and low magnification views
复制标题
小肝细胞癌的间质肿瘤细胞侵袭。
DOI：
10.1111/j.1440-1746.1994.tb01569.x
复制
发表时间：
1994
影响因子：
4.1
通讯作者：
Katsunori Wada
中科院分区：
文献类型：
--
作者：
F. Kondo;Y. Kondō;Y. Nagato;M. Tomizawa;Katsunori Wada
为了研究肝细胞癌（HCC）的发展过程，并寻找高分化HCC（wd-HCC）的组织学诊断线索，对小HCC的间质浸润进行了评价。研究材料包括35例小于3 cm的HCC，其中包括17例wd-HCC，18例中度或低分化的经典HCC（cl-HCC）和20例大再生结节（LRN）。间质浸润在显微镜下分为三种模式：（i）交叉型，其中HCC穿过肿瘤结节的纤维间隔侵入;（ii）纵向型，其中肿瘤细胞在纤维间隔内纵向生长;和（iii）不规则型，其中肝细胞癌不规则地侵入汇管区。在2例（12%）wd-HCC和10例（56%）cl-HCC中发现了交叉型，而在16例（94%）wd-HCC和8例（44%）cl-HCC中观察到了纵向型。不规则型多见于wd‐HCC（15例，88%）和cl‐HCC（12例，67%）。LRN未见间质浸润。即使在组织学标本的低倍镜下也可以识别间质性浸润，wd‐HCC的检出率为59%（10例），cl‐HCC为72%（13例）。
In order to study the process of hepatocellular carcinoma (HCC) development, and to search for a clue to histologic diagnosis of well‐differentiated HCC (wd‐HCC), interstitial invasion in small HCC was evaluated. The study material consisted of 35 cases of HCC that were smaller than 3 cm that comprised 17 cases of wd‐HCC, 18 cases of moderately or poorly differentiated classical HCC (cl‐HCC), and 20 cases of large regenerative nodules (LRN). Interstitial invasion was microscopically classified into three patterns: (i) crossing type, in which HCC was invading across fibrous septa of tumour nodules; (ii) longitudinal type, in which tumour cells were growing longitudinally within fibrous septa; and (iii) irregular type, in which the portal area was irregularly invaded by HCC. The crossing type was found in two cases (12%) of wd‐HCC and 10 cases (56%) of cl‐HCC while the longitudinal type was observed in 16 cases (94%) of wd‐HCC and eight cases (44%) of cl‐HCC. The irregular type was frequently seen in wd‐HCC (15 cases, 88%), and cl‐HCC (12 cases, 67%). No interstitial invasion was observed in LRN. Interstitial invasion could be recognized even in the low magnification view of histological specimens, with a detection rate of 59% (10 cases) in wd‐HCC and 72% (13 cases) in cl‐HCC.