Timolol: A β-Adrenergic Blocking Agent for the Treatment of Glaucoma
Timolol: A β-Adrenergic Blocking Agent for the Treatment of Glaucoma
复制标题
噻吗洛尔：一种用于治疗青光眼的 β-肾上腺素能阻断剂
DOI：
10.1001/archopht.1977.04450040067008
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发表时间：
1977
影响因子：
--
通讯作者：
H. Kaufman
中科院分区：
文献类型：
--
作者：
T. Zimmerman;H. Kaufman
·对30例青光眼患者进行了β-肾上腺素能阻滞剂马来酸替莫洛尔的研究。0.5%和1.5%的药物溶液对眼压有明显的降低作用。治疗7小时后，两种强度的噻吗洛尔眼压均较治疗前下降50%。没有检测到主观或客观的眼部或全身副作用。在整个研究过程中，视力和瞳孔反应与治疗前水平没有变化。β-肾上腺素能阻滞剂，特别是噻吗洛尔，可能是青光眼药物治疗的重要突破。(拱眼座95：601-604,1977)
• Timolol maleate, a β-adrenergic blocking agent, was studied in 30 patients With glaucoma. Significant intraocular pressure lowering was achieved with 0.5% and 1.5% solution of the drug. At seven hours following treatment, the IOP was lowered 50% from the pretreatment pressure with both strengths of timolol. There Were no subjective or objective ocular or systemic side effects detected. Visual acuity and pupil response were unchanged from pretreatment levels throughout the study. β-Adrenergic blocking agents and specifically timolol may be an important breakthrough for the medical management of glaucoma. (Arch Ophthalmol95:601-604, 1977)