Virus-specific neutralization by a soluble non-immunoglobulin factor found naturally in normal mouse sera.
Virus-specific neutralization by a soluble non-immunoglobulin factor found naturally in normal mouse sera.
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通过正常小鼠血清中天然存在的可溶性非免疫球蛋白因子进行病毒特异性中和。
DOI：
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发表时间：
1975
影响因子：
11.1
通讯作者：
R. Barnes
中科院分区：
文献类型：
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作者：
J. Levy;J. Ihle;O. Oleszko;R. Barnes
一种在小鼠血清中天然存在的低分子量物质，可中和小鼠异嗜性C型病毒。对内源性嗜亲性病毒无影响。这种中和因子不属于已知的免疫球蛋白类，其活性与可通过放射免疫沉淀法检测的抗病毒免疫球蛋白无关。异嗜性病毒的制剂吸收了小鼠血清中的这种中和活性。该因子对嗜X病毒的特异性表明，它代表了一种新认识到的宿主对内源性病毒的反应类型。其可能的作用，内源性C型病毒的调节被认为是。
A low-molecular-weight substance found naturally in mouse serum neutralizes mouse xenotropic C-type virus. It has no effect on endogenous ecotropic viruses. This neutralizing factor does not belong to the known immunogloblin classes, and its activity is not associated with the antivirus immunoglobulins that can be detected by radioimmunoprecipitation. Preparations of xenotropic virus absorb out this neutralizing activity in mouse sera. The specificity of this factor for X-tropic virus suggests that it represents a newly recognized type of response of the host to an endogenous virus. Its possible role in the regulation of endogenous C-type viruses is considered.