Feeding a Lysine-free Diet Decreases Food Intake without Changes in Hypothalamic Monoamine Concentrations in Growing Chicks
Feeding a Lysine-free Diet Decreases Food Intake without Changes in Hypothalamic Monoamine Concentrations in Growing Chicks
复制标题
饲喂不含赖氨酸的饮食可减少采食量，但不会改变生长中雏鸡的下丘脑单胺浓度
DOI：
10.2508/chikusan.70.484
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
T. Kubo
中科院分区：
文献类型：
--
作者：
K. Sugahara;Y. Shimoyama;H. Kato;T. Kubo
本研究的目的是确定早期减少无赖氨酸日粮摄入量与生长中的雏鸡下丘脑单胺浓度变化之间的关系。在对照组和无赖氨酸饮食7小时后，每小时测量一次食物摄入量。首先，在第三和第七个小时，小鸡被斩首，大脑被移除。使用HPLC-ECD系统测定下丘脑中的单胺。无赖氨酸饲粮的雏鸡在4 ~ 5小时和5 ~ 6小时的食物摄入量显著少于对照雏鸡。包括三个核在内的下丘脑区域单胺的初始浓度（SD平均值，ng / mg湿组织）如下：血清素（5-羟色胺，5-HT） 9.0±1.8，去甲肾上腺素2.0±0.5，肾上腺素1.51±0.38，多巴胺0.405±0.100。总的来说，下丘脑单胺的浓度不随饲料赖氨酸的消耗而显著变化。这些结果表明，通过饲喂不含赖氨酸的饮食来减少食物摄入量的早期发生在下丘脑单胺总浓度没有变化的情况下。
The objective of this study was to determine the relationship between the early reduction in intake of a lysine-free diet and the changes in hypothalamic monoamine concentration in growing chicks. Food intake was hourly measured after presentation of the control and lysine-free diets for 7 hours. At first, third and seventh hours, chicks were decapitated and brains were removed. Monoamines were determined in the hypothalamus using a HPLC-ECD system. Food intakes from 4 to 5 and 5 to 6 hours were significantly less in chicks on the lysine-free diet than in the control chicks. Initial concentrations of monoamines (mean values with SD, ng per mg wet tissue) in the hypothalamic area including the three nuclei were as follows; serotonin (5-hydroxytryptamine, 5-HT) 9.0±1.8, norepinephrine 2.0±0.5, epinephrine 1.51±0.38 and dopamine O.405±0.100. In general, the concentration of hypothalamic monoamines did not significantly vary with the dietary lysine depletion. These results indicated that the early reduction of food intake by feeding the lysine-free diet occurred without the change in the overall concentration of monoamines in the hypothalamus.
食欲和身体成分的调节。
DOI：
10.1096/fasebj.8.3.8143936
发表时间：
1994
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Weigle,DS
通讯作者：
Weigle,DS