Percutaneous Left Atrial Appendage Suture Ligation Using the LARIAT Device in Patients With Atrial Fibrillation Initial Clinical Experience
Percutaneous Left Atrial Appendage Suture Ligation Using the LARIAT Device in Patients With Atrial Fibrillation Initial Clinical Experience
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DOI：
10.1016/j.jacc.2012.06.046
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发表时间：
2013-07-09
影响因子：
24
通讯作者：
Lee, Randall J.
中科院分区：
文献类型：
--
作者：
Bartus, Krzysztof;Han, Frederick T.;Lee, Randall J.
目的 本研究的目的是确定通过经皮左心耳 (LAA) 结扎方法封堵左心耳 (LAA) 的有效性和安全性。 背景 栓塞性中风是心房颤动最具破坏性的后果。排除左心耳被认为可以降低栓塞性中风的风险。方法 89 名心房颤动患者入组，接受使用 LARIAT 装置经皮左心耳结扎术。基于导管的 LARIAT 装置由一个带有预先打结缝线的圈套器组成，该缝线在左心耳 (LAA) 上进行心外膜引导。立即通过经食管超声心动图 (TEE) 和对比透视检查确认 LAA 闭合，然后在 LAA 结扎后 1 天、30 天、90 天和 1 年进行 TEE。 结果 89 例患者中，85 例 (96%) 成功进行了 LAA 结扎。 85 名患者中有 81 名立即完全闭合。 85 名患者中的 3 名患有
Objectives The purpose of the study was to determine the efficacy and safety of left atrial appendage (LAA) closure via a percutaneous LAA ligation approach.Background Embolic stroke is the most devastating consequence of atrial fibrillation. Exclusion of the LAA is believed to decrease the risk of embolic stroke.Methods Eighty-nine patients with atrial fibrillation were enrolled to undergo percutaneous ligation of the LAA with the LARIAT device. The catheter-based LARIAT device consists of a snare with a pre-tied suture that is guided epicardially over the LAA. LAA closure was confirmed with transesophageal echocardiography (TEE) and contrast fluoroscopy immediately, then with TEE at 1 day, 30 days, 90 days, and 1 year post-LAA ligation.Results Eighty-five (96%) of 89 patients underwent successful LAA ligation. Eighty-one of 85 patients had complete closure immediately. Three of 85 patients had a