System Biology of Gene Regulation
System Biology of Gene Regulation
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DOI：
10.1007/978-1-59745-524-4_4
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发表时间：
2009-01-01
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影响因子：
--
通讯作者：
Baitaluk, Michael
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文献类型：
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作者：
Baitaluk, Michael
一个著名的笑话故事，展示了理论和实验之间传统上尴尬的联盟，并显示了实验生物学家和理论建模者之间的差异，当一所大学派遣生物学家，数学家，物理学家和计算机科学家进行徒步旅行时，试图刺激跨学科研究。在休息的时候，他们看到附近的一块地里有一头牛，领头的人问：“我想知道一个人怎么能决定一头牛的油的大小？由于牛是生物学上的物体，生物学家首先回答说：“我在这个地区见过很多牛，知道它是一头大母牛。数学家争辩说：“真正的体积是通过对描述牛身体外表面的数学函数进行积分来确定的。”物理学家建议：“让我们假设奶牛是一个球体。最后，计算机科学家变得紧张起来，他说他没有带他的计算机，因为山上没有互联网连接。在这个幽默但解释性的故事中，理论家提出的建议可以反映出许多实验生物学家的观点，即计算机科学家和理论家离生物现实太远，因此他们的理论和方法没有多大直接用处。相反，生物学家的陈述反映了许多传统理论和计算科学家的观点，即生物实验在很大程度上只是描述性的，缺乏严谨性，许多由此产生的生物学数据的功能相关性值得怀疑。当前生物学作为一门多学科科学的目标之一是将来自不同科学领域的人们聚集在同一座“山上”。让他们说同一种“语言”。当然，事实上，大多数实验生物学家在展示数据时，都会对结果进行解释和说明，而许多理论家/计算机科学家的目标是回答（或至少充分描述）生物相关性问题。因此，系统生物学可以被视为这样一种社会科学现象和一种新的实验和理论方法，其定义是通过使用跨学科的工具和人员来整合来自不同实验来源的生物系统中相互作用的复杂数据的策略。
A famous joke story that exhibits the traditionally awkward alliance between theory and experiment and showing the differences between experimental biologists and theoretical modelers is when a University sends a biologist, a mathematician, a physicist, and a computer scientist to a walking trip in an attempt to stimulate interdisciplinary research. During a break, they watch a cow in a field nearby and the leader of the group asks, "I wonder how one could decide oil the size of a cow?" Since a cow is a biological object, the biologist responded first: "I have seen many cows in this area and know it is a big cow." The mathematician argued, "The true volume is determined by integrating the mathematical function that describes the outer surface of the cow's body." The physicist suggested: "Let's assume the cow is a sphere .... " Finally the computer scientist became nervous and said that he didn't bring his computer because there is no Internet connection up there on the hill.In this humorous but explanatory story suggestions proposed by theorists can be taken to reflect the view of many experimental biologists that computer scientists and theorists arc too far removed from biological reality and therefore their theories and approaches are not of much immediate usefulness. Conversely, the statement of the biologist mirrors the view of many traditional theoretical and computational scientists that biological experiments arc for the most part simply descriptive, lack rigor, and that Much of the resulting biological data arc of questionable functional relevance.One of the goals of current biology as a Multidisciplinary science is to bring people from different scientific areas together oil the same "hill" and reach them to speak the same "language." In fact, of course, when presenting their data, most experimentalist biologists do provide an interpretation and explanation for the results, and many theorists/computer scientists aim to answer (or at least to fully describe) questions of biological relevance. Thus Systems biology could be treated as such a socioscientific phenomenon and a new approach to both experiments and theory that is defined by the strategy of pursuing integration of complex data about the interactions in biological systems from diverse experimental Sources Using interdisciplinary tools and personnel.