An overview on how cumulus cells interact with the oocyte in a condition with elevated NEFA levels in dairy cows
An overview on how cumulus cells interact with the oocyte in a condition with elevated NEFA levels in dairy cows
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DOI：
10.1016/j.anireprosci.2019.06.003
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发表时间：
2019-08-01
影响因子：
2.2
通讯作者：
Vos, Peter L. A. M.
中科院分区：
文献类型：
--
作者：
Aardema, Hilde;van Tol, Helena T. A.;Vos, Peter L. A. M.
人类和动物的代谢压力与生育力受损有关。代谢应激的一个主要特征是由于体内脂肪储备的动员，血液中游离脂肪酸（NEFAs）水平升高。奶牛在产卵期经历一段代谢应激期，即产后最初几周的负能量平衡（NEB）。在NEB时，饱和和不饱和的nefa都被动员起来作为细胞的替代能量供应，但特别是饱和的nefa会对体细胞产生有害影响。循环的NEFAs也反映在卵巢卵泡的卵泡液中，并因此到达卵母细胞复合物（COC），这意味着对发育中的卵母细胞有潜在的风险。为此，本文主要综述NEFAs对卵母细胞质量的影响。
Metabolic stress in humans and animals is associated with impaired fertility. A major characteristic of metabolic stress is elevated levels of free fatty acids (NEFAs) in blood due to mobilization of body fat reserves. Dairy cows undergo a period of metabolic stress during the pericalving period, the so-called negative energy balance (NEB) in the early weeks postpartum. At the time of NEB, both saturated and unsaturated NEFAs are mobilized to serve as an alternative energy supply for cells, however in particular saturated NEFAs can have a detrimental effect on somatic cells. Circulating NEFAs are also reflected in the follicular fluid of ovarian follicles and hence reach the cumulus-oocyte-complex (COC), which implies a potential risk for the developing oocyte. To this end, the current review focusses on the impact of NEFAs on the quality of the oocyte.