Posttraumatic stress disorder and total amyloid burden and amyloid-β 42/40 ratios in plasma: Results from a pilot study of World Trade Center responders
Posttraumatic stress disorder and total amyloid burden and amyloid-β 42/40 ratios in plasma: Results from a pilot study of World Trade Center responders
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DOI：
10.1016/j.dadm.2019.01.003
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发表时间：
2019-12-01
影响因子：
5.3
通讯作者：
Luft, Benjamin J.
中科院分区：
文献类型：
--
作者：
Clouston, Sean A. P.;Deri, Yael;Luft, Benjamin J.
慢性创伤后应激障碍（PTSD）与记忆力差和各种退行性脑神经病变负担增加有关。本初步研究的目的是确定创伤后应激障碍是否与世界贸易中心（WTC）应答者中基于血浆的神经变性神经病理生物标志物的变化有关。方法34例WTC应答者在取血15分钟内进行快速冷冻。当时对PTSD症状进行了评估。年龄、性别和WTC暴露时间从医疗记录中获得。使用超灵敏的单分子酶联免疫吸附法检测血浆中淀粉样蛋白- β (A β) 42/40比率、总A β、总tau和神经丝光（NfL）的分布。对照组取自同一机构收集和检测的健康对照者。结果抽血时WTC应答者的平均年龄为53岁。根据症状严重程度，一半为PTSD阳性（PTSD+）。与健康对照组相比，WTC应答者血浆中A β 42/A β 40比值较低，但总tau和NfL水平较高。PTSD+状态与较低的血浆A β负荷和较高的A β 42/A β 40比值相关。研究结果表明，PTSD可能与A β、tau和NfL相关的血浆标志物的改变有关，这突出了PTSD状态与WTC应答者神经退行性神经病理之间的潜在关联。
Introduction Chronic posttraumatic stress disorder (PTSD) is associated with poor memory and increased burden of various degenerative cerebral neuropathologies. The goal of this pilot study was to determine whether PTSD was associated with changes in plasma-based neuropathological biomarkers of neurodegeneration among World Trade Center (WTC) responders.Methods Thirty-four WTC responders had blood drawn and flash-frozen within 15 minutes of retrieval. PTSD symptoms were assessed at that time. Age, sex, and WTC exposure duration were obtained from medical records. Plasma was assayed in duplicate using an ultra-sensitive single-molecule enzyme-linked immunosorbent assay to examine the distribution of amyloid-beta (A beta) 42/40 ratios, total A beta, total tau, and neurofilament light (NfL). The comparison group was drawn from a bank of healthy controls collected and assayed at the same facility.ResultsThe average age of WTC responders at blood draw was 53 years. Half were PTSD positive (PTSD+) as indicated by symptom severity. WTC responders had lower A beta 42/A beta 40 ratios but higher total tau and NfL levels in the plasma than healthy controls. PTSD+ status was associated with lower plasma A beta load and higher A beta 42/A beta 40 ratios.Discussion Findings suggest that PTSD may be associated with alterations in plasma markers related to A beta, tau, and NfL, highlighting the potential association between PTSD status and neurodegenerative neuropathology in WTC responders.