Effects of fructooligosaccharides on the absorption of magnesium and calcium by cecectomized rats.
Effects of fructooligosaccharides on the absorption of magnesium and calcium by cecectomized rats.
复制标题
低聚果糖对盲肠切除大鼠吸收镁和钙的影响。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
S. Kimura
中科院分区：
文献类型：
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作者：
A. Ohta;M. Ohtuki;T. Takizawa;H. Inaba;T. Adachi;S. Kimura
我们之前报道过，饲喂低聚果糖（FO）可增加大鼠对钙（Ca）、镁（Mg）和磷（P）的表观吸收。我们认为这种现象与大肠中 FO 的发酵之间存在重要的相关性。然而，确切的机制仍有待表征。因此，我们使用盲肠切除的大鼠进行了一项矿物质平衡研究，以确定 FO 影响矿物质吸收的管腔部分。假手术大鼠和盲肠切除大鼠饲喂对照饮食（不含 FO）或 FO 饮食（每公斤饲料含 50 g FO）28 天。饲喂 FO 饮食会降低假手术大鼠盲肠和结肠的管腔 pH 值。在盲肠切除的大鼠中，喂食 FO 饮食也会降低结肠内的 pH 值。因此，FO在盲肠切除大鼠的结肠中发酵。然而，盲肠切除术改变了粪便的酸性成分。 FO-饮食的喂养增加了假手术大鼠对钙和镁的吸收。在盲肠切除大鼠中，FO 饮食增加了镁的吸收，但没有增加钙的吸收。这些结果表明，当大鼠喂食 FO 时，钙和镁的吸收机制是不同的。
We reported previously that feeding of fructooligosaccharides (FO) increased the apparent absorption of calcium (Ca), magnesium (Mg) and phosphorus (P) in rats. We suggested that there was an important correlation between this phenomenon and fermentation of FO in the large intestine. However, the precise mechanism remained to be characterized. Therefore, we performed a mineral-balance study to identify the segment of lumen in which FO affects mineral absorption, using cecectomized rats. Sham-operated rats and cecectomized rats were fed a control diet (without FO) or an FO-diet (containing 50 g of FO per kg of feed) for 28 days. Feeding of the FO-diet decreased the luminal pH in the cecum and colon in the sham-operated rats. In the cecectomized rats, feeding of the FO-diet also decreased the luminal pH in the colon. Thus, FO was fermented in the colon of the cecectomized rats. However, the acid composition of feces was altered by cecectomy. Feeding of the FO-diet increased the absorption of Ca and Mg in the sham-operated rats. In the cecectomized rats, the FO-diet increased the absorption of Mg but did not increase the absorption of Ca. These results suggest the mechanisms for the absorption of Ca and Mg when rats are fed an FO are different.