Relevance of CYP3A5 Expression on the Clinical Outcome of Patients With Renal Cell Carcinoma
Relevance of CYP3A5 Expression on the Clinical Outcome of Patients With Renal Cell Carcinoma
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DOI：
10.21873/anticanres.15029
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发表时间：
2021-05
影响因子：
2
通讯作者：
J. Matsumoto;Yumi Kotera;S. Watari;Koichi Takeuchi;H. Ueki;T. Koyama;K. Wada;Masachika Fujiyoshi;Y. Nasu;N. Ariyoshi
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文献类型：
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作者：
J. Matsumoto;Yumi Kotera;S. Watari;Koichi Takeuchi;H. Ueki;T. Koyama;K. Wada;Masachika Fujiyoshi;Y. Nasu;N. Ariyoshi
背景/目的：本研究旨在阐明肾细胞癌（RCC）患者CYP 3A 5表达的详细特征及其与临床预后的关系。患者和方法：本研究回顾性纳入了124例在冈山大学医院接受治疗的日本RCC患者。检测最常见的CYP 3A 5基因多态性CYP 3A 5 *3，以及各组织中CYP 3A 5 mRNA和蛋白的表达水平。结果：肾细胞癌组织中CYP 3A 5 mRNA和蛋白的表达较癌旁正常肾组织明显下调。高水平的CYP 3A 5 mRNA表达显著延长了癌症特异性生存期（p=0.004）和总生存期（p=0.002）。CYP 3A 5 mRNA表达水平被确定为癌症特异性生存期和总生存期的重要独立预后因素。结论：CYP 3A 5可作为肾细胞癌诊断和治疗方案制定的潜在指标。
Background/Aim: This study aimed to elucidate the detailed characteristics of CYP3A5 expression and the association between CYP3A5 expression and clinical outcomes in patients with renal cell carcinoma (RCC). Patients and Methods: This study retrospectively enrolled 124 Japanese patients with RCC treated at the Okayama University Hospital. The commonest CYP3A5 gene polymorphism, CYP3A5*3, and expression levels of CYP3A5 mRNA and protein in each tissue were examined. Results: Expression of CYP3A5 mRNA and protein in RCC tissues was significantly down-regulated compared to that in adjacent normal tissues. High level of CYP3A5 mRNA expression significantly extended cancer-specific survival (p=0.004) and overall survival (p=0.002). The CYP3A5 mRNA expression level was identified as a significant independent prognostic factor for both cancer-specific survival and overall survival. Conclusion: CYP3A5 could serve as a potential marker for prognostication and treatment planning for patients with RCC.