SUBCORTICAL SITES MEDIATING SYMPATHETIC RESPONSES FROM INSULAR CORTEX IN RATS
SUBCORTICAL SITES MEDIATING SYMPATHETIC RESPONSES FROM INSULAR CORTEX IN RATS
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DOI：
10.1152/ajpregu.1990.258.1.r245
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发表时间：
1990-01-01
影响因子：
--
通讯作者：
CHEN, SJ
中科院分区：
文献类型：
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作者：
CECHETTO, DF;CHEN, SJ
刺激岛叶皮质会引发许多自主反应。岛叶皮层直接投射到下丘脑外侧区、臂旁核和孤束核，而孤束核又直接投射到交感神经节前区。为了确定这些皮层下部位中的哪一个介导岛皮层引起的交感神经反应，记录了将突触阻断剂钴注射到每个区域之前和之后肾神经活动的变化。连续监测氯醛糖或尿烷麻醉大鼠的血压、心率和肾神经活动。单脉冲电刺激（200μA，1ms）分别引起岛叶皮质中升压和降压部位肾神经活动的早期增加或减少。下丘脑外侧区域注射钴 (500 nl) 可减弱神经反应 10-100%。将钴注射到孤束核中显着增强了从岛叶皮质加压部位获得的神经反应的初始增加。臂旁核注射不影响神经反应。这些结果表明，在从岛叶皮质到交感神经系统的通路中，下丘脑外侧区域存在强制突触。
Stimulation of the insular cortex elicits a number of autonomic responses. The insular cortex projects directly to the lateral hypothalamic area, the parabrachial nucleus, and the nucleus of the solitary tract, which in turn project directly to sympathetic preganglionic areas. To determine which of these subcortical sites mediates sympathetic responses evoked from the insular cortex, changes in renal nerve activity were recorded before and after injection of the synaptic blocking agent cobalt into each of these regions. Blood pressure, heart rate, and renal nerve activity were continuously monitored in chloralose or urethan-anesthetized rats. Single-pulse electrical stimulation (200 .mu.A, 1 ms) elicited either an early increase or decrease in renal nerve activity from pressor and depressor sites, respectively, in the insular cortex. Cobalt injections (500 nl) into the lateral hypothalamic area attenuated the nerve response 10-100%. Cobalt injections into the nucleus of the solitary tract significantly enhanced the initial increase in the nerve response obtained from pressor sites in the insular cortex. Injections into the parabrachial nucleus did not affect the nerve responses. These results suggest that there is a mandatory synapse in the lateral hypothalamic area in the pathway from the insular cortex to the sympathetic nervous system.