Possible Mechanism of Detoxifying Effect of Selenium on the Toxicity of Mercury Compounds
Possible Mechanism of Detoxifying Effect of Selenium on the Toxicity of Mercury Compounds
复制标题
硒对汞化合物毒性的解毒作用的可能机制
DOI：
10.1007/978-1-4757-9071-9_17
复制
发表时间：
1991
影响因子：
2.7
通讯作者：
A. Naganuma
中科院分区：
文献类型：
--
作者：
N. Imura;A. Naganuma
硒化合物与汞联合应用可显著降低汞的急性毒性，途径包括：1)减少无机汞急性毒性的主要靶点--汞在肾脏的蓄积；2)延长汞和硒作为惰性高分子络合物在血液中的滞留时间，使汞和硒在血液中的滞留时间延长；3)汞和硒在肝和肾脏等不同器官中形成稳定的、不可扩散的络合物。
Co-administration of selenium compounds with mercuric mercury resulted in remarkable depression of acute toxicity of mercury through 1) reduction of mercury accumulation in the kidneys, a major target of acute toxicity of inorganic mercury, by forming high molecular weight complexes consisting of Hg, Se and proteins in the blood, which were hardly filtered through glomerulus; 2) elongation of retention of mercury and selenium as inert high molecular weight complexes in the blood, especially in the erythrocytes; 3) formation of stable and non-diffusible complexes of Hg and Se in various organs such as the liver and kidneys.