The association between mechanical and biochemical/histological characteristics in diabetic and non-diabetic plantar soft tissue
The association between mechanical and biochemical/histological characteristics in diabetic and non-diabetic plantar soft tissue
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DOI：
10.1016/j.jbiomech.2016.08.021
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发表时间：
2016-10-03
影响因子：
2.4
通讯作者：
Wang, Yak-Nam
中科院分区：
文献类型：
--
作者：
Ledoux, William R.;Pai, Shruti;Wang, Yak-Nam
糖尿病和随后的下肢溃疡并发症导致潜在的截肢，仍然是美国重要的医疗保健问题，即使截肢率下降。已经充分证明糖尿病可以改变机械性能（即，增加的硬度），尽管这一发现并不普遍。类似地，在足底软组织中发现了生物化学和组织学变化，但是，与机械变化一样，这些发现在所有研究中并不一致。我们小组的工作已经证明糖尿病增加足底软组织模量和增加弹性间隔厚度。本研究的目的是探讨机械，生物化学和组织学特性之间的关联。使用先前收集的数据，进行线性混合效应回归。相关性较弱;在所测试的32个中，只有3个（当考虑位置时的隔膜厚度的模量、总胶原的能量损失和胶原/弹性蛋白比率的能量损失）是统计学显著的，没有一个的R-2大于0.10。平均值的主要差异是组织硬度增加和间隔壁厚度增加，这两种趋势都得到了文献的支持。然而，由于相关性较弱，可能是另一个未检查的生化因素（可能是胶原交联）与机械组织变化相关。爱思唯尔有限公司出版
Diabetes, and the subsequent complication of lower limb ulcers leading to potential amputation, remains an important health care problem in United States, even with declining amputation rates. It has been well documented that diabetes can alter the mechanical properties (i.e., increased stiffness) of the plantar soft tissue, although this finding is not universal. Similarly, biochemical, and histological changes have been found in the plantar soft tissue, but, as with the mechanical changes, these findings are not consistent across all studies. Our group's work has demonstrated that diabetes increases plantar soft tissue modulus and increases elastic septal thickness. The purpose of the current study was to explore the association between mechanical, biochemical and histological properties. Using previously collected data, a linear mixed effects regression was conducted. The correlations were weak; of the 32 that were tested, only 3 (modulus to septal thickness when location was accounted for, energy loss to total collagen, and energy loss to collagen/elastin ratio) were statistically significant, none with an R-2 greater than 0.10. The main differences in the means were increased tissue stiffness and increased septal wall thickness, both trends were supported in the literature. However, as the correlations were weak, it is likely that another unexamined biochemical factor (perhaps collagen crosslinking) is associated with the mechanical tissue changes. Published by Elsevier Ltd.