Detection and identification of animal emotionality-exposing stress incubation in Mice
Detection and identification of animal emotionality-exposing stress incubation in Mice
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小鼠情绪暴露应激孵化的检测和鉴定
DOI：
10.1109/iciibms.2017.8279754
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
G. Stephens
中科院分区：
文献类型：
--
作者：
B. Kuhn;Ray X. Lee;G. Stephens
尽管标准行为测试来测量实验动物的情绪有着悠久的历史并被广泛使用，但其方法和逻辑却受到了严厉的批评。在这里，我们通过原理验证测试方法和精细行为分析解决了基本的逻辑和定量问题。报道的方法能够检测到信息丰富的行为细节，并进一步证明小鼠急性心理创伤后的压力潜伏期。相比之下，标准分析给出了不确定的结果。这种方法提供了技术进步，允许使用标准行为测试探索广泛的潜在测量，并为支持所得出的动物情绪提供更坚实的基础。
Despite the long history and wide use of standard behavioral tests to measure emotion in laboratory animals, the approach and logic have been heavily criticized. Here we solved the fundamental logical and quantitative problems by a proof-of-principle testing approach with fine-scale behavioral analysis. The reported approach was able to detect informative behavioral details and further prove stress incubation after acute psychological trauma in mice. Standard analyses, in contrast, gave inconclusive results. This approach provides a technical advance allowing exploration of a wide range of potential measurements using standard behavioral tests, and a more solid basis supporting the concluded animal emotionality.
影响因子：
25
作者：
Funamizu, Akihiro;Kuhn, Bernd;Doya, Kenji
通讯作者：
Doya, Kenji