BIOSYNTHESIS OF DOLICHOL AND CHOLESTEROL IN RAT-LIVER PEROXISOMES
BIOSYNTHESIS OF DOLICHOL AND CHOLESTEROL IN RAT-LIVER PEROXISOMES
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DOI：
10.1016/0300-9084(93)90074-3
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发表时间：
1993-01-01
期刊：
影响因子：
3.9
通讯作者：
DALLNER, G
中科院分区：
文献类型：
--
作者：
ERICSSON, J;APPELKVIST, EL;DALLNER, G
离体大鼠肝过氧化物酶体含有完整的酶机制所需的胆固醇和长胆固醇的合成法呢焦磷酸。此外，乙酰辅酶A和焦磷酸法呢酯之间的甲羟戊酸途径的初始部分的全部或部分也存在于过氧化物酶体中。过氧化物酶体中的胆固醇和长胆固醇生物合成比ER中更完全，因为过氧化物酶体含有高浓度的固醇载体蛋白-2，其是刺激长胆固醇和胆固醇生物合成的蛋白质。大约50%和20%的总肝多萜醇和胆固醇生物合成与大鼠肝过氧化物酶体，分别。在饮食和药物治疗后，这些脂质的合成在过氧化物酶体和ER中表现出不同的调节。
Isolated rat liver peroxisomes contain the complete enzymatic machinery required for the synthesis of both cholesterol and dolichol from farnesyl pyrophosphate. Additionally, the whole or part of the initial portion of the mevalonate pathway between acetyl-CoA and farnesyl pyrophosphate is also present in peroxisomes. Cholesterol and dolichol biosynthesis in peroxisomes is more complete than in ER since peroxisomes contain high concentrations of sterol carrier protein-2, a protein that stimulates both dolichol and cholesterol biosynthesis. Approximately 50 and 20% of the total hepatic dolichol and cholesterol biosynthesis is associated with rat liver peroxisomes, respectively. Upon dietary and drug treatments the synthesis of these lipids displays different regulation in peroxisomes and ER.