Abnormal bronchoalveolar lavage in asymptomatic dairy farmers. Study of lymphocytes.
Abnormal bronchoalveolar lavage in asymptomatic dairy farmers. Study of lymphocytes.
复制标题
无症状奶农的支气管肺泡灌洗异常。
DOI：
10.1164/arrd.1984.130.6.1046
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
J. Hébert
中科院分区：
文献类型：
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作者：
Y. Cormier;J. Bélanger;J. Beaudoin;M. Laviolette;R. Beaudoin;J. Hébert
对24名无症状奶农进行了支气管肺泡灌洗(BAL)。血清沉淀物阳性者13例(组1)，阴性对照组11例(组2)。所有人都不吸烟，以前没有肺部疾病病史。24例受试者中有13例(第1组9例，第2组4例)BAL中淋巴细胞比例高(大于或等于20%)。用OKT_3、OKT_4和OKT_8检测外周血T淋巴细胞亚群，OKT_3分别为58.5+/-15.6%和58.5+/-8.7%，OKT_4=40.6+/-10.7%和39.9+/-10.0%，OKT_8=21.5+/-10.6%和22.4+/-8.0%(p=NS)。当将BAL中淋巴细胞比例高的受试者与淋巴细胞比例正常的受试者进行比较时，这些淋巴细胞特征也是相似的。鸡红细胞特异性(MF包被)淋巴细胞毒作用(组1，45.2+/-29.5%，组2，49.2+/-23.4%)和非特异性淋巴细胞毒性(组1，43.9+/-28.6%，组2，37.9+/-18.0%)也相似。我们的结论是，大量无症状的奶农在他们的BAL(“肺泡炎”)中淋巴细胞的百分比增加，这些受试者的外周血淋巴细胞具有正常的亚群，如用单抗评估的那样，并具有正常的淋巴细胞毒性。
Bronchoalveolar lavage (BAL) was performed on 24 asymptomatic dairy farmers. Thirteen had serum precipitins to Micropolyspora faeni (MF) antigens (Group 1), and 11 were seronegative control subjects (Group 2). All were nonsmokers and had no history of previous lung disease. Thirteen of 24 subjects (9 in Group 1 and 4 in Group 2) had a high percentage of lymphocytes (greater than or equal to 20%) in their BAL. The T-lymphocyte subpopulations as estimated by OKT3, OKT4, and OKT8 monoclonal antibody reactivity were measured in peripheral blood lymphocytes; OKT3 = 58.5 +/- 15.6% for Group 1, and 58.5 +/- 8.7% for Group 2; OKT4 = 40.6 +/- 10.7% and 39.9 +/- 10.0%; OKT8 = 21.5 +/- 10.6% and 22.4 +/- 8.0%, respectively (p = NS). These lymphocyte characteristics were also similar when subjects with a high percentage of lymphocytes in BAL were compared to those with a normal percentage. Specific (MF-coated) chicken erythrocyte lymphocytotoxicity (Group 1, 45.2 +/- 29.5%, Group 2, 49.2 +/- 23.4%), and nonspecific lymphocytotoxicity (Group 1, 43.9 +/- 28.6%, Group 2, 37.9 +/- 18.0%) were also similar. We conclude that a large number of asymptomatic dairy farmers have an increased percentage of lymphocytes in their BAL ("alveolitis") and that peripheral blood lymphocytes in these subjects have normal subpopulations, as assessed by monoclonal antibodies, and normal lymphocytotoxicity.