Rat tendon morphologic and functional changes resulting from soft tissue mobilization
Rat tendon morphologic and functional changes resulting from soft tissue mobilization
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DOI：
10.1097/00005768-199703000-00005
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发表时间：
1997-03-01
期刊：
影响因子：
--
通讯作者：
Sevier, TL
中科院分区：
文献类型：
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作者：
Davidson, CJ;Ganion, LR;Sevier, TL
增强软组织动员（ASTM）是一种新的无创软组织动员技术，已成功地用于治疗各种肌肉骨骼疾病。本研究的目的是确定ASTM治疗对酶诱导的大鼠跟腱损伤的形态和功能特征的影响。如下分配四组，每组5只大鼠：（A）对照组，（B）肌腱炎组，（C）肌腱炎+ASTM组，（D）单独ASTM组。诱导胶原酶损伤，并使手术部位愈合3周。在术后第21、25、29和33天，对C组和D组的跟腱进行ASTM，持续3分钟，共进行4次治疗。每次治疗前收集步态数据。末次治疗后1wk取跟腱。标本制备光学和电子显微镜，1型和III型胶原和纤连蛋白的免疫染色进行。光学显微镜检查显示肌腱炎+ASTM治疗组的成纤维细胞增殖增加。虽然大鼠的愈合可能不会直接转化为人类的愈合，但本研究的结果表明，ASTM可能通过增加成纤维细胞募集来促进愈合。
Augmented Soft Tissue Mobilization (ASTM) is it new non-invasive soft tissue mobilization technique which has been used successfully to treat a variety of musculoskeletal disorders. The purpose of this study was to determine the effects of ASTM therapy on the morphological and functional characteristics of enzyme induced injured rat Achilles tendons. Four groups of five rats were allocated as follows: (A) control, (B) tendinitis, (C) tendinitis plus ASTM, and (D) ASTM alone. ColIagenase injury was induced, and the surgical site was allowed to heal for 3 wk. ASTM was performed on the Achilles tendon of groups C and D for 3 min on postoperative days 21, 25, 29, and 33 for a total of four treatments. Gait data were gathered prior to each treatment. The Achilles tendons of each group were harvested 1 wk after the last treatment. Specimens were prepared for light and electron microscopy, and immunostaining for type 1 and type III collagen and fibronectin was performed. Light microscopy showed increased fibroblast proliferation in the tendinitis plus ASTM treatment group. Although healing in rats may not translate directly to healing in humans, the findings of this study suggest that ASTM may promote healing via increased fibroblast recruitment.