Unexpected Copper-Catalyzed Cascade Synthesis of Quinazoline Derivatives
Unexpected Copper-Catalyzed Cascade Synthesis of Quinazoline Derivatives
复制标题
铜催化喹唑啉衍生物的意外级联合成
DOI：
10.1021/jo401908g
复制
发表时间：
2013-11-15
影响因子：
3.6
通讯作者：
Wu, Huayue
中科院分区：
文献类型：
--
作者：
Chen, Zhongyan;Chen, Jiuxi;Wu, Huayue
使用六水合硝酸铈和氯化铵的组合，开发了（2-氨基苯基）甲醇与醛的铜催化级联反应的第一个例子，以中等至优异的收率产生了各种2-取代喹唑啉。这种转化的效率通过与多种官能团的兼容性得到证明。因此，该方法代表了一种方便实用的2-取代喹唑啉衍生物的合成策略。
The first example of a copper-catalyzed cascade reaction of (2-aminophenyl)methanols with aldehydes using the combination of cerium nitrate hexahydrate and ammonium chloride has been developed, leading to a wide range of 2-substituted quinazolines in moderate to excellent yields. The efficiency of this transformation was demonstrated by compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of 2-substituted quinazoline derivatives.