Strategies for the elimination of hepatitis C virus infection as a public health threat in the United States.
Strategies for the elimination of hepatitis C virus infection as a public health threat in the United States.
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DOI：
10.1007/s11901-018-0394-x
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Lo Re V 3rd
中科院分区：
文献类型：
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作者：
Gowda C;Lo Re V 3rd
针对慢性丙型肝炎病毒（HCV）的直接作用抗病毒治疗方案于2014年问世，这些高度治愈性的治疗方法有可能降低HCV相关的发病率和死亡率，减少传播，并消除HCV感染这一公共卫生问题。本文综述了美国国家科学院、工程院和医学院对美国消除HCV战略的建议。为了实现到2030年将HCV发病率降低90%和将HCV相关死亡率降低60%的拟议目标，迫切需要改善HCV诊断和与护理的联系;通过扩大抗病毒治疗规模减少HCV相关疾病;降低HCV发病率;加强HCV监测，以确定随着时间的推移实现HCV消除目标。虽然消除丙型肝炎病毒是可行的，但这一国家努力的成功将需要关键利益相关者的持续合作和关键资源投资，包括医疗和公共卫生界、立法者、社区组织者和患者倡导者。
Direct-acting antiviral regimens for chronic hepatitis C virus (HCV) became available in 2014, and these highly curative therapies have the potential to reduce HCV-associated morbidity and mortality, decrease transmission, and eliminate HCV infection as a public health problem. This review summarizes the recommendations by the National Academies of Sciences, Engineering, and Medicine for a US strategy for HCV elimination. To achieve proposed targets of reducing HCV incidence by 90% and decreasing HCV-related mortality by 60% by 2030, there is a critical need to improve HCV diagnosis and linkage to care; reduce HCV-related disease by antiviral treatment scale-up; reduce HCV incidence; and strengthen HCV surveillance to determine achievement of HCV elimination targets over time. While HCV elimination is feasible, success of this national effort will require ongoing collaboration and critical resource investment by key stakeholders, including medical and public health communities, legislators, community organizers, and patient advocates.