High-pressure needle interface for thermoplastic microfluidics
High-pressure needle interface for thermoplastic microfluidics
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DOI：
10.1039/b812812j
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发表时间：
2009-01-01
期刊：
影响因子：
6.1
通讯作者：
DeVoe, D. L.
中科院分区：
文献类型：
--
作者：
Chen, C. F.;Liu, J.;DeVoe, D. L.
已经开发了用于热塑性微流体的鲁棒的和低死体积的世界到芯片接口。高压流体端口采用插入到与嵌入式微通道对准的配合孔中的不锈钢针，其中过盈配合用于增加耐压性。或者，还展示了拧入配合孔中的自攻螺纹针。在这两种情况下，平底针端口直接抵靠微通道基底，确保低界面死体积。低色散观察到染料带通过接口。针端口提供了足够的拔出力，用于需要高内部流体压力的应用，例如液相色谱，其中无环氧树脂接口与高于40 MPa的内部微通道压力兼容。
A robust and low dead volume world-to-chip interface for thermoplastic microfluidics has been developed. The high pressure fluidic port employs a stainless steel needle inserted into a mating hole aligned to an embedded microchannel, with an interference fit used to increase pressure resistance. Alternately, a self-tapping threaded needle screwed into a mating hole is also demonstrated. In both cases, the flat bottom needle ports seat directly against the microchannel substrate, ensuring low interfacial dead volumes. Low dispersion is observed for dye bands passing the interfaces. The needle ports offer sufficient pull-out forces for applications such as liquid chromatography that require high internal fluid pressures, with the epoxy-free interfaces compatible with internal microchannel pressures above 40 MPa.