Duodenal-Jejunal Bypass Maintains Gut Permeability by Suppressing Gut Inflammation
Duodenal-Jejunal Bypass Maintains Gut Permeability by Suppressing Gut Inflammation
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DOI：
10.1007/s11695-019-03922-4
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发表时间：
2019-09-01
期刊：
影响因子：
2.9
通讯作者：
Takasu, Chie
中科院分区：
文献类型：
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作者：
Kashihara, Hideya;Shimada, Mitsuo;Takasu, Chie
本研究的目的是研究大鼠空肠-空肠旁路（DJB）后和注射胰高血糖素样肽-1（GLP-1）受体类似物后的肠道炎症和通透性。方法12只16周龄雄性肥胖糖尿病大鼠随机分为DJB组、假手术组和GLP-1受体激动剂利拉鲁肽组。术后8周观察3组肠道炎症反应及紧密连接蛋白（claudin-1）的表达。结果DJB组肠道炎症细胞因子水平明显低于利拉鲁肽组。DJB组Claudin-1的免疫荧光染色强度强于利拉鲁肽组。结论总之，DJB手术可能通过抑制肠道炎症来维持肠道通透性。
Background The aim of this study was to investigate gut inflammation and permeability in rats after duodenal-jejunal bypass (DJB) and in rats injected with a glucagon-like peptide-1 (GLP-1) receptor analog. Methods Twelve male 16-week-old obese diabetic rats were divided into three groups: the DJB group, the sham group, and the group injected daily with a GLP-1 receptor agonist (liraglutide). Gut inflammation and the expression of tight junction protein (claudin-1) were analyzed in the three groups at 8 weeks after surgery. Results The DJB group showed significantly lower levels of gut inflammatory cytokines than the liraglutide group. Claudin-1 showed stronger intensity on immunofluorescent staining in the DJB group than that in the liraglutide group. Conclusions In summary, DJB surgery might maintain gut permeability via suppression of gut inflammation.