Non-lethal growth inhibition by arresting the starch utilization system of clinically relevant human isolates of Bacteroides dorei
Non-lethal growth inhibition by arresting the starch utilization system of clinically relevant human isolates of Bacteroides dorei
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DOI：
10.1039/c9md00301k
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发表时间：
2019-11-01
期刊：
影响因子：
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通讯作者：
Whitehead, Daniel C.
中科院分区：
文献类型：
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作者：
Santilli, Anthony D.;Russell, Jordan T.;Whitehead, Daniel C.
我们描述了抑制淀粉利用系统（SUS）属于多氏拟杆菌的各种菌株在一个非致死的方式使用小分子探针，阿卡波糖。阿卡波糖的浓度低至5 μ M就显著阻碍了B的生长。并增加培养物的倍增时间。这种拟杆菌的成功抑制与包括I型糖尿病在内的几种疾病状态有关。该方法继续探索一种新的潜在途径，通过对其成分的策略性操纵来干预与人类肠道微生物群组成异常变化相关的疾病。
We describe the inhibition of the starch utilization system (Sus) belonging to various strains of Bacteroides dorei in a non-lethal manner using the small molecule probe, acarbose. Concentrations of acarbose as low as 5 mu M significantly impede the growth of B. dorei and increase the doubling time of cultures. The successful inhibition of this species of Bacteroides is relevant to several disease states including type I diabetes mellitus. This method continues to explore a new, potential route to intervene in illnesses associated with aberrant changes in the composition of the human gut microbiota through the strategic manipulation of its constituents.