Abnormal regional homogeneity in Parkinson's disease: a resting state fMRI study
Abnormal regional homogeneity in Parkinson's disease: a resting state fMRI study
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帕金森病的异常区域同质性：静息态功能磁共振成像研究
DOI：
10.1016/j.crad.2015.10.006
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发表时间：
2016-01-01
影响因子：
2.6
通讯作者：
Li, K.
中科院分区：
文献类型：
--
作者：
Li, Y.;Liang, P.;Li, K.
目的：在控制结构萎缩的情况下，通过测量静息时血氧水平依赖（BOLD）功能MRI （fMRI）信号，研究帕金森病（PD）的脑功能改变。材料与方法：本研究纳入23例PD患者和20例年龄、性别、教育水平匹配的正常对照（NC）。静息状态fMRI和结构MRI数据采集。通过区域均匀性（ReHo）方法测量静息状态下的脑活动，通过基于体素的形态学（VBM）分析获得灰质（GM）体积。然后进行双样本t检验，以结构萎缩作为协变量来检测组间差异。结果：VBM分析显示，PD患者左侧额上回、左侧中央旁小叶和左侧额中回的GM体积比NC患者减少。NC和PD患者的ReHo存在广泛差异。与NC相比，PD患者在运动网络上表现出明显的改变，包括右侧初级感觉皮层（S1）的ReHo降低，而左侧运动前区（PMA）和左侧背外侧前额叶皮层（DLPFC）的ReHo升高。此外，PD患者左枕上回（SOG）的一个簇也显示ReHo升高。结论：目前的研究结果表明，PD患者运动和非运动皮质的ReHo发生了显著的变化，与年龄、性别、文化程度和结构萎缩无关。因此，本研究提示ReHo异常可作为PD诊断的潜在生物标志物，并进一步深入了解该疾病的生物学机制。(C) 2015皇家放射学院。Elsevier Ltd.出版。版权所有。
AIM: To examine the functional brain alterations in Parkinson's disease (PD) by measuring blood oxygenation level dependent (BOLD) functional MRI (fMRI) signals at rest while controlling for the structural atrophy.MATERIALS AND METHODS: Twenty-three PD patients and 20 age, gender, and education level matched normal controls (NC) were included in this study. Resting state fMRI and structural MRI data were acquired. The resting state brain activity was measured by the regional homogeneity (ReHo) method and the grey matter (GM) volume was attained by the voxel-based morphology (VBM) analysis. Two-sample t-test was then performed to detect the group differences with structural atrophy as a covariate.RESULTS: VBM analysis showed GM volume reductions in the left superior frontal gyrus, left paracentral lobule, and left middle frontal gyrus in PD patients as compared to NC. There were widespread ReHo differences between NC and PD patients. Compared to NC, PD patients showed significant alterations in the motor network, including decreased ReHo in the right primary sensory cortex (S1), while increased ReHo in the left premotor area (PMA) and left dorsolateral prefrontal cortex (DLPFC). In addition, a cluster in the left superior occipital gyrus (SOG) also showed increased ReHo in PD patients.CONCLUSION: The current findings indicate that significant changes of ReHo in the motor and non-motor cortices have been detected in PD patients, independent of age, gender, education level, and structural atrophy. The present study thus suggests ReHo abnormalities as a potential biomarker for the diagnosis of PD and further provides insights into the biological mechanism of the disease. (C) 2015 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.