Cognitive impairment in pulmonary arterial hypertension.
Cognitive impairment in pulmonary arterial hypertension.
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DOI：
10.1002/acn3.51867
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发表时间：
2023-10
影响因子：
5.3
通讯作者：
Fredericks, Carolyn A.
中科院分区：
文献类型：
--
作者：
Heller, Sloane;See, Claudia;Singh, Inderjit;Fredericks, Carolyn A.
肺动脉高压（PAH）是以进行性肺血管重构为特征，导致肺动脉压力异常升高和右心功能不全。有证据表明PAH包括认知障碍。然而，认知损害综合征尚未得到很好的描述，PAH的潜在机制以及心肺功能障碍和认知功能障碍之间的关系尚不清楚。我们对患有PAH的成年受试者进行了认知评估和当天次最大心肺运动测试。在26%的受试者中发现了提示血管性认知障碍的额叶皮质下综合征，并与肺血管重塑的非侵入性标志物相关。
Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary vascular remodeling with resultant abnormal increase in pulmonary artery pressure and right heart dysfunction. There is evidence that PAH includes cognitive impairment. However, the cognitive impairment syndrome has not been well described, and both the underlying mechanism and the relationship between cardiopulmonary and cognitive dysfunction in PAH are unknown. We performed cognitive evaluations and same day sub‐maximum cardiopulmonary exercise testing on adult subjects with PAH. A frontal–subcortical syndrome suggestive of vascular cognitive impairment was found in 26% of subjects and was associated with noninvasive markers of pulmonary vascular remodeling.
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