Bioactive saponins and glycosides. XXVII. Structures of new cucurbitane-type triterpene glycosides and antiallergic constituents from Citrullus colocynthis.
Bioactive saponins and glycosides. XXVII. Structures of new cucurbitane-type triterpene glycosides and antiallergic constituents from Citrullus colocynthis.
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DOI：
10.1248/cpb.55.428
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发表时间：
2007-03
影响因子：
1.7
通讯作者：
M. Yoshikawa;T. Morikawa;Hisanori Kobayashi;A. Nakamura;Koudai Matsuhira;Seikou Nakamura;H. Matsuda
中科院分区：
文献类型：
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作者：
M. Yoshikawa;T. Morikawa;Hisanori Kobayashi;A. Nakamura;Koudai Matsuhira;Seikou Nakamura;H. Matsuda
西瓜果实的甲醇提取物对小鼠耳被动皮肤过敏反应具有抑制作用。从其甲醇提取物中分离得到两个新的葫芦烷型三萜苷类化合物：colocynthosides A和B。根据化学和物理化学证据鉴定了colocynthosides A和B的结构。此外，主要的葫芦烷型三萜糖苷葫芦素E 2-O-β-D-吡喃葡萄糖苷及其苷元葫芦素E在100和1.25 mg/kg，p.o.，分别
The methanolic extract from the fruit of Citrullus colocynthis showed an inhibitory effect on ear passive cutaneous anaphylaxis reactions as a type I allergic model in mice. From the methanolic extract, two new cucurbitane-type triterpene glycosides, colocynthosides A and B, were isolated together with 17 known constituents. The structures of colocynthosides A and B were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal cucurbitane-type triterpene glycoside, cucurbitacin E 2-O-beta-D-glucopyranoside, and its aglycon, cucurbitacin E, exhibited the antiallergic activity at a dose of 100 and 1.25 mg/kg, p.o., respectively.