Sex-Specific Associations of Brain-Derived Neurotrophic Factor and Cardiorespiratory Fitness in the General Population
Sex-Specific Associations of Brain-Derived Neurotrophic Factor and Cardiorespiratory Fitness in the General Population
复制标题
DOI：
10.3390/biom9100630
复制
发表时间：
2019-10
期刊：
影响因子：
5.5
通讯作者：
Marie-Lena Schmalhofer;M. Markus;J. C. Gras;Juliane Kopp;D. Janowitz;H. Grabe;S. Gross;R. Ewert;S. Gläser;Diana Albrecht;Ina Eiffler;H. Völzke;N. Friedrich;M. Nauck;A. Steveling;S. Könemann;K. Wenzel;S. Felix;M. Dörr;M. Bahls
中科院分区：
文献类型：
--
作者：
Marie-Lena Schmalhofer;M. Markus;J. C. Gras;Juliane Kopp;D. Janowitz;H. Grabe;S. Gross;R. Ewert;S. Gläser;Diana Albrecht;Ina Eiffler;H. Völzke;N. Friedrich;M. Nauck;A. Steveling;S. Könemann;K. Wenzel;S. Felix;M. Dörr;M. Bahls
脑源性神经营养因子（BDNF）最初被认为是神经元特异性的。同时，这种神经营养素也由骨骼肌细胞分泌，并因运动而增加。BDNF是否与心肺功能（CRF）有关目前尚不清楚。我们分析了一般人群中血清BDNF水平与CRF的相关性（来自德国东北部的波美拉尼亚健康研究（SHIP-TREND）; n = 1607，51%为女性;中位年龄48岁）。调整年龄、身高、吸烟、体脂、瘦体重、体力活动和抑郁的性别分层线性回归模型分析了BDNF与最大耗氧量（VO 2 peak）、体重标准化最大耗氧量（VO 2 peak/kg）和无氧阈值耗氧量（VO2@AT）之间的关系。在女性中，VO 2 peak、VO 2 peak/kg和VO2@AT升高1 mL/min与2.43 pg/mL（95%置信区间[CI]：1.16 - 3.69 pg/mL; p = 0.0002），150.66 pg/mL（95% CI：63.42至237.90 pg/mL; p = 0.0007）和2.68 pg/mL（95% CI：0.5至4.8 pg/mL; p = 0.01）更高的BDNF血清浓度。在男性中没有发现显著的相关性。需要进一步的研究来了解CRF和BDNF之间的性别特异性关联。
The brain-derived neurotrophic factor (BDNF) was initially considered to be neuron-specific. Meanwhile, this neurotrophin is peripherally also secreted by skeletal muscle cells and increases due to exercise. Whether BDNF is related to cardiorespiratory fitness (CRF) is currently unclear. We analyzed the association of serum BDNF levels with CRF in the general population (Study of Health in Pomerania (SHIP-TREND) from Northeast Germany; n = 1607, 51% female; median age 48 years). Sex-stratified linear regression models adjusted for age, height, smoking, body fat, lean mass, physical activity, and depression analyzed the association between BDNF and maximal oxygen consumption (VO2peak), maximal oxygen consumption normalized for body weight (VO2peak/kg), and oxygen consumption at the anaerobic threshold (VO2@AT). In women, 1 mL/min higher VO2peak, VO2peak/kg, and VO2@AT were associated with a 2.43 pg/mL (95% confidence interval [CI]: 1.16 to 3.69 pg/mL; p = 0.0002), 150.66 pg/mL (95% CI: 63.42 to 237.90 pg/mL; p = 0.0007), and 2.68 pg/mL (95% CI: 0.5 to 4.8 pg/mL; p = 0.01) higher BDNF serum concentration, respectively. No significant associations were found in men. Further research is needed to understand the sex-specific association between CRF and BDNF.