Nanobowl-Supported Liposomes Improve Drug Loading and Delivery
Nanobowl-Supported Liposomes Improve Drug Loading and Delivery
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纳米碗支持的脂质体改善药物装载和递送
DOI：
10.1021/acs.nanolett.0c00495
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发表时间：
2020-06-10
期刊：
影响因子：
10.8
通讯作者：
Fang, Chao
中科院分区：
文献类型：
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作者：
Chen, Zhong-Jian;Yang, Si-Cong;Fang, Chao
由于药物在循环中的渗漏，用于癌症治疗的脂质体药物输送可能受到限制。在这里，我们开发了一种新的方法来提高主动负载的脂质体阿霉素(DOX)的稳定性，方法是在脂质体水腔中嵌入一个僵硬的纳米猫头鹰。纳米鸟支持的脂质体DOX(DOX@NbLipo)可以抵抗血浆蛋白和血流剪切力的影响，防止药物泄漏。这种方法改善了药物对肿瘤部位的输送，并增强了抗肿瘤效果。与其他修饰脂质体表面和组合物以提高稳定性的方法相比，该方法设计了一种全水纳米脂质体空腔的物理支撑。纳米鸟稳定脂质体是提高载体稳定性和药物释放的一种简单有效的方法。
Liposomal drug delivery for cancer therapy can be limited due to drug leakage in circulation. Here, we develop a new method to enhance the stability of actively loaded liposomal doxorubicin (DOX) through embedding a stiff nanobowl in the liposomal water cavity. Nanobowl-supported liposomal DOX (DOX@NbLipo) resists the influence of plasma protein and blood flow shear force to prevent drug leakage. This approach yields improved drug delivery to tumor sites and enhanced antitumor efficacy. Compared to alternative methods of modifying liposome surface and composition for stability, this approach designs a physical support for an all-aqueous nanoliposomal cavity. Nanobowl stabilization of liposomes is a simple and effective method to improve carrier stability and drug delivery.