Thiamin deficiency and heart failure: the current knowledge and gaps in literature
Thiamin deficiency and heart failure: the current knowledge and gaps in literature
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DOI：
10.1007/s10741-014-9432-0
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发表时间：
2015-01-01
影响因子：
4.6
通讯作者：
Keith, Mary
中科院分区：
文献类型：
--
作者：
Ahmed, Mavra;Azizi-Namini, Parastoo;Keith, Mary
心力衰竭（HF）的管理对工业化国家的患者和医疗保健系统都是一个重大挑战。硫胺素是一种必需的辅酶在能源生产的反应，燃料心肌收缩。因此，硫胺素缺乏症（TD）可能通过限制可用于收缩的能量而导致心肌无力。先前的研究报告了HF患者TD的患病率范围很广（3- 91%）。补充维生素B1对心力衰竭患者的影响尚无定论。迄今为止进行的研究受到以下因素的限制：样本量小、评估硫胺素浓度的间接方法、方法不一致、使用不切实际的硫胺素补充方法、关注住院患者，以及缺乏用于评估心脏功能的稳健技术。未来需要进行大型前瞻性研究和随机对照试验，以提高我们对与慢性疾病相关的营养需求变化以及补充剂的临床益处的理解。
The management of heart failure (HF) represents a significant challenge for both patients as well as the healthcare system in industrialized countries. Thiamin is a required coenzyme in the energy-producing reactions that fuel myocardial contraction. Therefore, thiamin deficiency (TD) may contribute to myocardial weakness by limiting the energy available for contraction. Previous studies have reported a wide range in the prevalence of TD in patients with HF (3-91 %). The impact of thiamin supplementation in patients with HF is inconclusive. Studies conducted to date are limited by their small sample size, indirect methods of assessing thiamin concentration, methodological inconsistencies, use of impractical means of thiamin supplementation, a focus on hospitalized patients, and lack a robust technique for the assessment of cardiac function. Future large prospective studies and randomized controlled trials are needed to improve our understanding of any change in nutritional requirements associated with chronic disease as well as the clinical benefit of supplementation.