Actions of endogenous vasopressin and oxytocin on anterior pituitary hormone secretion.
Actions of endogenous vasopressin and oxytocin on anterior pituitary hormone secretion.
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内源性加压素和催产素对垂体前叶激素分泌的作用。
DOI：
10.1159/000126427
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发表时间：
1993
影响因子：
4.1
通讯作者：
McCann,SM
中科院分区：
文献类型：
--
作者：
Franci,CR;Anselmo-Franci,JA;Kozlowski,GP;McCann,SM
为探讨内源性加压素（VP）和催产素（OT）在调节垂体前叶激素释放中的意义，将抗加压素（AB VP）和抗催产素（AB OT）的抗血清分别注入清醒、去卵巢大鼠的第三脑室（3V），使内源性VP和OT免疫中和。在显微注射之前和之后的不同时间收集血液样品。注射正常兔血清（NRS）的对照组与脑室内注射AB-OT或AB-VP 24 h的对照组之间血浆LH、FSH、PRL和TSH浓度无差异。血浆生长激素（GH）在注射NRS后4 h显著下降，6 h仍保持较低水平，24 h回升至接近初始水平。脑室内微量注射AB-VP后，血浆GH水平在1 ~ 24 h内明显升高，而对照组无明显变化。脑室内注射AB-VP或AB-OT可显著降低血浆ACTH水平，但AB-VP的作用时间更长，持续时间为注射后6 h而非4 h。因此，内源性催产素可能通过刺激生长抑素分泌和/或抑制GH释放激素分泌或通过这两种作用在控制基础GH释放中发挥作用。另一方面，内源性血管加压素和催产素在控制基础ACTH释放中起生理上显著的刺激作用。
To evaluate the significance of endogenous vasopressin and oxytocin in control of anterior pituitary hormone release, antiserum against vasopressin (AB-VP) or oxytocin (AB-OT) were microinjected into the third ventricle (3V) of conscious, ovariectomized rats to immunoneutralize endogenous VP or OT, respectively. Blood samples were collected just before and at different times after the microinjections. There were no differences in the plasma LH, FSH, PRL and TSH concentrations between control groups injected into the 3V with normal rabbit serum (NRS) and groups submitted to the intraventricular injection of AB-OT or AB-VP for 24 h after the injections. Plasma growth hormone (GH) declined significantly by 4 h after NRS injection, remained low at 6 h and had rebounded to nearly initial levels at 24 h. This pattern was not changed by microinjection of AB-VP, but plasma GH increased significantly compared to initial values in the period from 1 to 24 h after intraventricular microinjection of AB-OT. The intraventricular injection of AB-VP or AB-OT significantly decreased plasma ACTH; however, the effect of AB-VP was more prolonged and persisted for 6 rather than 4 h after injection. Thus, endogenous oxytocin may play a role in the control of basal GH release probably by stimulating somatostatin secretion and/or inhibiting GH-releasing hormone secretion or by both actions. On the other hand, both endogenous vasopressin and oxytocin play a physiologically significant stimulatory role in the control of basal ACTH release.