ER to Golgi-Dependent Protein Secretion: The Conventional Pathway
ER to Golgi-Dependent Protein Secretion: The Conventional Pathway
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DOI：
10.1007/978-1-4939-3804-9_1
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发表时间：
2016-01-01
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影响因子：
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通讯作者：
Viotti, Corrado
中科院分区：
文献类型：
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作者：
Viotti, Corrado
分泌是存在于每个有机体中的细胞过程，它将可溶的蛋白质和货物运送到细胞外空间。在真核生物中，常规的蛋白质分泌(CPS)是分泌蛋白质从内质网(ER)运输到高尔基体(GA)，然后通过分泌小泡或分泌颗粒运输到质膜(PM)的运输途径。本书回顾了细胞生物学研究中有助于阐明CPS的基本步骤；它描述了真核细胞中最突出的常规分泌蛋白质的例子，以及调节这一过程每一步所需的分子机制。
Secretion is the cellular process present in every organism that delivers soluble proteins and cargoes to the extracellular space. In eukaryotes, conventional protein secretion (CPS) is the trafficking route that secretory proteins undertake when are transported from the endoplasmic reticulum (ER) to the Golgi apparatus (GA), and subsequently to the plasma membrane (PM) via secretory vesicles or secretory granules. This book chapter recalls the fundamental steps in cell biology research contributing to the elucidation of CPS; it describes the most prominent examples of conventionally secreted proteins in eukaryotic cells and the molecular mechanisms necessary to regulate each step of this process.