Development and initial testing of a pediatric centrifugal blood pump.
Development and initial testing of a pediatric centrifugal blood pump.
复制标题
儿科离心血泵的开发和初步测试。
DOI：
10.1016/0003-4975(95)01022-x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Borovetz,HS
中科院分区：
文献类型：
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作者：
Litwak,P;Butler,KC;Thomas,DC;Taylor,LP;Macha,M;Yamazaki,K;Konishi,H;Kormos,RL;Griffith,BP;Borovetz,HS
我们正在开发一种小型离心血泵，用作新生儿和儿科患者的临时心脏辅助装置。该泵的预充量非常低，仅为13 mL。一个小的电机定子也被设计，这导致了一个设备，可以放置在非常接近病人，从而最大限度地减少整体电路volume. METHODSTABILITY迄今已包括在体外血液动力学性能，在体外溶血生成，并在体内评价5羔羊体重5.5至21公斤。2只羔羊接受从颈外静脉到颈动脉的外周插管，而另外3只从左心房到颈动脉插管。体外数据表明，在这些条件下，泵的容量范围为0.3至3.0 L/min，溶血发生率非常低。在体内，泵的功能令人满意的时间长达148小时，旁路似乎是由动物耐受良好。在所有动物实验期间，血浆游离血红蛋白水平保持低于25 mg/dL。所有的设备都是血栓免费在prestation. CONCLUSION我们得出结论，该设备具有优点，作为一种替代目前过大的系统用于新生儿和儿科心脏援助。此外，一个慢性新生儿羔羊模型，以评估儿科循环辅助装置已成功开发。
BACKGROUNDWe are developing a miniaturized centrifugal blood pump for use as a temporary cardiac assist device in neonatal and pediatric sized patients. This pump has a very low priming volume of 13 mL. A small motor stator has also been designed, which resulted in a device that can be placed very close to the patient, thereby minimizing overall circuit volume.METHODSTesting to date has included in vitro hemodynamic performance, in vitro hemolysis generation, and in vivo evaluation in 5 lambs weighing 5.5 to 21 kg. Two lambs underwent peripheral cannulation from external jugular vein to carotid artery, whereas 3 others were cannulated from left atrium to carotid artery.RESULTSIn vitro data demonstrated pump capacity spanning 0.3 to 3.0 L/min and very low hemolysis generation at these conditions. In vivo, the pump functioned satisfactorily for periods up to 148 hours, and the bypass appeared to be well tolerated by the animals. Plasma free hemoglobin levels remained less than 25 mg/dL during all animal experiments. All devices were thrombus-free at explantation.CONCLUSIONSWe conclude that this device has merit as an alternative to current oversized systems used for neonatal and pediatric cardiac assistance. In addition, a chronic neonatal lamb model in which to evaluate pediatric circulatory assist devices has been developed successfully.