Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta.
Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta.
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DOI：
10.1083/jcb.101.2.363
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发表时间：
1985-08
期刊：
影响因子：
--
通讯作者：
Majerus PW
中科院分区：
文献类型：
--
作者：
Maruyama I;Bell CE;Majerus PW
我们已经使用从胎盘分离的人血栓调节蛋白的抗体来研究这种蛋白C激活的辅因子在人体组织中的分布。用抗生物素蛋白-生物素过氧化物酶免疫细胞化学染色法，在动脉、静脉、毛细血管和毛细血管的内皮细胞上发现血栓调节蛋白。血栓调节蛋白未检测到肝窦衬里细胞或毛细血管后高内皮淋巴结微静脉，虽然后者含有另一种内皮抗原，血管性血友病因子。其他含有血栓调节蛋白抗原的细胞是胎盘合体滋养层细胞。合体滋养细胞的血栓调节蛋白主要位于形成母体血窦的质膜表面。合体滋养层细胞也用血管性血友病因子抗体染色，这意味着这些细胞具有多种内皮功能。血栓调节蛋白抗原发现在所有器官的研究，与大脑的显着例外。
We have used antibodies to human thrombomodulin isolated from placenta to investigate the distribution of this cofactor for protein C activation in human tissues. Thrombomodulin was found on endothelial cells of arteries, veins, capillaries, and lymphatics by immunocytochemical staining using an avidin-biotin peroxidase method. Thrombomodulin was not detected on sinusoidal lining cells of liver or on postcapillary high-endothelial venules of lymph node, although the latter contained another endothelial antigen, von Willebrand factor. Other cells noted to contain thrombomodulin antigen are those of the syncytiotrophoblast in placenta. The thrombomodulin in syncytiotrophoblast was primarily on the plasma membrane surface that forms the maternal blood sinus. Syncytiotrophoblast also stained with antibodies to von Willebrand factor, which implies that these cells have multiple endothelial functions. Thrombomodulin antigen was found in all organs studied, with the notable exception of brain.