A Map of Octopaminergic Neurons in the Drosophila Brain
A Map of Octopaminergic Neurons in the Drosophila Brain
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DOI：
10.1002/cne.21966
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发表时间：
2009-04-20
影响因子：
2.5
通讯作者：
Tanimoto, Hiromu
中科院分区：
文献类型：
--
作者：
Busch, Sebastian;Selcho, Mareike;Tanimoto, Hiromu
生物胺章鱼胺调节无脊椎动物的多种行为。在单个神经元水平上，由于其结构简单和可接近性，周围神经系统中的作用模式被充分理解。为了阐明单个章鱼胺能神经元在复杂行为调制中的作用，需要对中枢神经系统中的连接进行详细分析。在这里，我们提出了一个全面的解剖图候选章鱼胺能神经元在成年果蝇的大脑：包括上和食管下神经节。Flp输出技术的应用使27种类型的个体章鱼胺能神经元的可视化。基于它们的形态和遗传标记的分布，我们发现大多数章鱼胺能神经元投射到多个脑结构，树突和突触前区域有明显的分离。虽然它们的主要树突局限于特定的大脑区域，但每种细胞类型的目标是不同的，但定义的，分布在整个中枢神经系统的神经末梢。这将使它们能够构成分配给不同神经元过程的调制的组合模块。该图可以为章鱼胺能系统的功能构成提供解剖学框架。它也是大脑中特定神经递质的单细胞组织的模型。J. Comp.神经元513：643-667，2009. (C)2009 Wiley-Liss，Inc.
The biogenic amine octopamine modulates diverse behaviors in invertebrates. At the single neuron level, the mode of action is well understood in the peripheral nervous system owing to its simple structure and accessibility. For elucidating the role of individual octopaminergic neurons in the modulation of complex behaviors, a detailed analysis of the connectivity in the central nervous system is required. Here we present a comprehensive anatomical map of candidate octopaminergic neurons in the adult Drosophila brain: including the supra- and subesophageal ganglia. Application of the Flp-out technique enabled visualization of 27 types of individual octopaminergic neurons. Based on their morphology and distribution of genetic markers, we found that most octopaminergic neurons project to multiple brain structures with a clear separation of dendritic and presynaptic regions. Whereas their major dendrites are confined to specific brain regions, each cell type targets different, yet defined, neuropils distributed throughout the central nervous system. This would allow them to constitute combinatorial modules assigned to the modulation of distinct neuronal processes. The map may provide an anatomical framework for the functional constitution of the octopaminergic system. It also serves as a model for the single-cell organization of a particular neurotransmitter in the brain. J. Comp. Neurol. 513: 643-667, 2009. (C) 2009 Wiley-Liss, Inc.