Thrombocytopenia after aortic valve replacement with the Freedom Solo stentless bioprosthesis.
Thrombocytopenia after aortic valve replacement with the Freedom Solo stentless bioprosthesis.
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DOI：
10.1510/icvts.2007.169326
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发表时间：
2008-08-01
影响因子：
--
通讯作者：
Liebold, Andreas
中科院分区：
文献类型：
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作者：
Yerebakan, Can;Kaminski, Alexander;Liebold, Andreas
在主动脉瓣置换术中，无支架生物瓣膜的血流动力学优于带支架生物瓣膜，长期性能得到改善。我们观察到在植入后第一天内接受Sorin Freedom Solo主动脉无支架心包生物瓣膜的患者出现重度血小板减少症。在40例患者的配对分析中，比较了无支架（Sorin Freedom Solo）或带支架（Sorin Mitroflow）牛心包生物瓣膜植入后2周内的绝对和相对血小板计数。除术前值外，Mitroflow组在所有时间点的绝对血小板计数均较高。在Mitroflow组中，平均血小板计数在术后第3天中度下降至初始值的至少60%，并在术后第8天完全恢复。在Freedom Solo组中，血小板丢失显著更严重（术后第4天的最小相对值为25%），随访期间未恢复（术后第13天为60%）。Freedom Solo组的8名患者发生了临界血小板下降，
Stentless bioprostheses have been considered to achieve superior hemodynamics over stented bioprostheses for aortic valve replacement with improved long-term performance. We observed severe thrombocytopenia in patients who received the Sorin Freedom Solo aortic stentless pericardial bioprosthesis within the first days after implantation. Absolute and relative platelet counts within 2 weeks after implantation of either a stentless (Sorin Freedom Solo) or a stented (Sorin Mitroflow) bovine pericardial bioprosthesis were compared in a matched-pairs analysis in 40 patients. Except the preoperative values, absolute platelet count was higher at all time points in the Mitroflow group. In the Mitroflow group, the mean platelet count moderately dropped to a minimum of 60% of the initial value on POD 3 and fully recovered by POD 8. In the Freedom Solo group, platelet loss was significantly more severe (minimum relative value 25% on POD 4) with no recovery during follow-up (60% on POD 13). Eight patients of the Freedom Solo group experienced a critical platelet drop towards