Study protocol for a national cohort of adults focused on respiratory health: the American Lung Association Lung Health Cohort (ALA-LHC) Study.
Study protocol for a national cohort of adults focused on respiratory health: the American Lung Association Lung Health Cohort (ALA-LHC) Study.
复制标题
关注呼吸健康的国家成人队列研究方案：美国肺脏协会肺健康队列(ALA-LHC)研究。
DOI：
10.1136/bmjopen-2021-053342
复制
发表时间：
2021-07-05
期刊：
影响因子：
2.9
通讯作者：
American Lung Association Airway’s Clinical Research Network
中科院分区：
文献类型：
--
作者：
Reyfman PA;Sugar E;Hazucha H;Hixon J;Reynolds C;Bose S;Dransfield MT;Han MK;Estepar RSJ;Rice MB;Washko GR;Carnethon M;Kalhan R;American Lung Association Airways Clinical Research Network;American Lung Association Airway’s Clinical Research Network
目前调查呼吸系统疾病的框架是基于将肺部健康定义为没有肺部疾病。为了制定一种全面的方法来预防肺部疾病的发展，有必要评估从理想到受损肺部健康的全范围。美国肺脏协会（ALA）肺部健康队列是一项新的、基于人群的队列研究，主要关注未诊断出严重呼吸系统疾病的千禧一代成员的肺部健康特征。参与者将于2021年开始参加基线研究访问，并将寻求资金支持未来的研究考试，作为纵向队列研究的一部分。这项研究将是至关重要的，在整个成人生命过程中发展肺部健康的新范式。这项研究将利用ALA航空临床研究中心网络的现有基础设施，在2021年4月至2024年12月期间在美国39个地点招募4000名年龄在25至35岁之间的参与者。研究程序将包括体格评估、肺活量测定、胸部CT扫描、加速度计和收集鼻上皮内膜液、鼻上皮细胞、血液和尿液。参与者将完成关于他们的社会人口特征、家庭住址历史和暴露、工作历史和暴露、病史、肺部健康和健康行为和活动的问卷调查。这项研究得到了约翰霍普金斯医学机构审查委员会的批准。研究结果将通过同行评议的期刊和专业会议向科学界传播。普通公众将直接通过包括官方公共网站在内的ALA基础设施获得科学发现。未鉴定的数据集将存入BioLINCC，未鉴定的生物标本可与有限使用的数据集一起提供给合格的研究人员。
The current framework for investigating respiratory diseases is based on defining lung health as the absence of lung disease. In order to develop a comprehensive approach to prevent the development of lung disease, there is a need to evaluate the full spectrum of lung health spanning from ideal to impaired lung health. The American Lung Association (ALA) Lung Health Cohort is a new, population-based, cohort study focused primarily on characterising lung health in members of the millennial generation without diagnosed severe respiratory disease. Participants will be enrolled for the baseline study visit starting in 2021, and funding will be sought to support future study exams as part of a longitudinal cohort study. This study will be crucial for developing a novel paradigm of lung health throughout the adult life course. This study will leverage the existing infrastructure of the ALA Airways Clinical Research Centers network to enrol 4000 participants between ages 25 and 35 years old at 39 sites across the USA between April 2021 and December 2024. Study procedures will include physical assessment, spirometry, chest CT scan, accelerometry and collection of nasal epithelial lining fluid, nasal epithelial cells, blood and urine. Participants will complete questionnaires about their sociodemographic characteristics, home address histories and exposures, work history and exposure, medical histories, lung health and health behaviours and activity. The study was approved by the Johns Hopkins Medicine Institutional Review Board. Findings will be disseminated to the scientific community through peer-reviewed journals and at professional conferences. The lay public will receive scientific findings directly through the ALA infrastructure including the official public website. Deidentified datasets will be deposited to BioLINCC, and deidentified biospecimens may be made available to qualified investigators along with a limited-use datasets.
登录
查看更多内容
DOI：
10.1016/j.jaci.2018.07.041
发表时间：
2019-03
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Togias A;Gergen PJ;Hu JW;Babineau DC;Wood RA;Cohen RT;Makhija MM;Khurana Hershey GK;Kercsmar CM;Gruchalla RS;Liu AH;Wang E;Kim H;Lamm CI;Bacharier LB;Pillai D;Sigelman SM;Gern JE;Busse WW
通讯作者：
Busse WW
DOI：
10.1164/rccm.201801-0120pp
发表时间：
2018-08-15
影响因子：
24.7
作者：
Reyfman, Paul A.;Washko, George R.;Kalhan, Ravi
通讯作者：
Kalhan, Ravi
影响因子：
4.8
作者：
Ash, Samuel Y.;Harmouche, Rola;Washko, George R.
通讯作者：
Washko, George R.
影响因子：
2.9
作者：
Polak, Maciej;Szafraniec, Krystyna;Pajak, Andrzej
通讯作者：
Pajak, Andrzej
影响因子：
1.5
作者：
Keene, Oliver N.;Jones, Mark R. K.;Anderson, Julie
通讯作者：
Anderson, Julie