SMALL-CELL CARCINOMA OF PROSTATE - EFFECTIVENESS OF HORMONAL VERSUS CHEMOTHERAPY
SMALL-CELL CARCINOMA OF PROSTATE - EFFECTIVENESS OF HORMONAL VERSUS CHEMOTHERAPY
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DOI：
10.1016/0090-4295(92)90235-o
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发表时间：
1992-05-01
期刊：
影响因子：
2.1
通讯作者：
ZHANG, G
中科院分区：
文献类型：
--
作者：
MOORE, SR;REINBERG, Y;ZHANG, G
前列腺小细胞癌是一种罕见且具有快速死亡过程的疾病。自1977年以来，世界文献中报告了47例病例，本文介绍了另外3例病例的数据。我们回顾的目的是确定激素与化疗的有效性。50例中有34例有已知的临床病史。四名患者没有接受治疗，并且在平均2.75个月内全部死于疾病。6例患者因尸检发现小细胞癌而被排除在我们的综述之外。另有5例因既往诊断为腺癌时已行激素+/-化疗，但发展为小细胞癌后未行特异性治疗而被忽略。在剩下的19例中，只有2例存活。一个在激素治疗后43个月仍然活着，另一个在激素治疗和化疗开始后6个月仍然活着。5名患者只接受了激素治疗，没有一例产生反应。4例患者在激素治疗失败后接受化疗，也在短时间内死于疾病。然而，另外8例患者接受了立即化疗+/-激素治疗，临床缓解期明显延长。因此，尽管小细胞癌是一种致命的疾病，但应考虑立即化疗以促进更好的临床缓解。
Small cell carcinoma of the prostate is rare and associated with a rapidly fatal course. Since 1977, 47 cases have been reported in the world literature with data from 3 additional cases presented herein. The purpose of our review was to determine the effectiveness of hormonal versus chemotherapy. Thirty-four of the 50 cases have known clinical histories. Four patients were not treated, and all were dead of their disease within an average of 2.75 months. Six patients were eliminated from our review because small cell carcinoma was discovered at autopsy. Another 5 cases were omitted because hormonal +/- chemotherapy had already been given for a previous diagnosis of adenocarcinoma, but no specific therapy was given once the small cell carcinoma developed. Of the remaining 19 cases, only 2 have survived. One is still alive forty-three months after hormonal treatment, and another is alive with disease six months after the initiation of hormonal therapy and chemotherapy. Five patients were given hormonal therapy only, and none of them responded. In 4 patients chemotherapy was given after hormonal therapy had failed, and they too died of their disease within a short period of time. However, an additional 8 patients were treated with immediate chemotherapy +/- hormonal therapy and had substantially longer clinical remissions. Therefore, although small cell carcinoma is a uniformly fatal disease, immediate chemotherapy should be considered to promote better clinical remissions.