Comparison of the 68Ga-DOTATATA PET/CT, FDG PET/CT, and MIBG SPECT/CT in the Evaluation of Suspected Primary Pheochromocytomas and Paragangliomas
Comparison of the 68Ga-DOTATATA PET/CT, FDG PET/CT, and MIBG SPECT/CT in the Evaluation of Suspected Primary Pheochromocytomas and Paragangliomas
复制标题
68Ga-DOTATATA PET/CT、FDG PET/CT 和 MIBG SPECT/CT 评估疑似原发性嗜铬细胞瘤和副神经节瘤的比较
DOI：
10.1097/rlu.0000000000001674
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发表时间：
2017-07-01
影响因子：
10.6
通讯作者：
Zhang, Jingjing
中科院分区：
文献类型：
--
作者：
Jing, Hongli;Li, Fang;Zhang, Jingjing
包括 CT 和 MRI 在内的解剖成像方式是评估原发性嗜铬细胞瘤或副神经节瘤的主要手段。然而，经常需要核医学成像来确定病变的性质。这项调查的目的是评估哪种常用核医学方式在这种临床环境中可能具有更好的诊断价值。方法 8 例疑似原发性嗜铬细胞瘤或原发性副神经节瘤患者和 1 例已知嗜铬细胞瘤患者纳入分析。在 8 名未知诊断的患者中，7 名已通过解剖成像方式提出建议，而其中 1 名患者最初的解剖成像解释为阴性。所有9名患者均接受了68Ga-DOTATATA PET/CT、FDG PET/CT和MIBG SPECT/CT以进行进一步评估。将影像学结果与术后病理和随访进行比较。结果 68Ga-DOTATATA PET/CT 和 MIBG SPECT/CT 均准确识别出 9 个原发肿瘤，而 FDG PET/CT 显示 9 个原发肿瘤中有 8 个的活性增加。 68Ga-DOTATATA 和 FDG PET/CT 均能够检测多发性内分泌肿瘤综合征患者 MIBG 研究中未显示的相关肾上腺外病变。结论 68Ga-DOTATATA PET/CT 可以成为评估疑似原发性嗜铬细胞瘤或副神经节瘤的核医学影像选择，特别是在多发性内分泌肿瘤综合征的情况下。
Anatomical imaging modalities including CT and MRI are the mainstay of evaluation of primary pheochromocytoma or paraganglioma. However, nuclear medicine imaging is frequently necessary to determine the nature of the lesions. The purpose of this investigation is to assess which commonly used nuclear medicine modality might have a better diagnostic value in this clinical setting. Methods Eight patients who had been suspected of having either primary pheochromocytoma or primary paraganglioma and 1 patient with known pheochromocytoma were included in the analysis. Among the 8 patients without known diagnosis, 7 had been suggested by anatomical imaging modalities, whereas one of them presented with initial negative anatomical imaging interpretation. All of 9 patients underwent 68Ga-DOTATATA PET/CT, FDG PET/CT, and MIBG SPECT/CT for further evaluation. The imaging findings were compared with postsurgical pathology and follow-up. Results Both 68Ga-DOTATATA PET/CT and MIBG SPECT/CT accurately identified 9 primary tumors, whereas FDG PET/CT showed increased activity in 8 of 9 primary tumors. Both 68Ga-DOTATATA and FDG PET/CT are able to detect associated extra-adrenal lesions not shown on MIBG study in patients with multiple endocrine neoplasia syndrome. Conclusions 68Ga-DOTATATA PET/CT could be the nuclear medicine imaging choice to evaluate suspected primary pheochromocytoma or paraganglioma, especially in the situation of multiple endocrine neoplasia syndrome.