Radiofrequency Ablation by a 21-Gauge Internally Cooled Electrode: Ex Vivo and In Vivo Evaluation by Rat Liver
Radiofrequency Ablation by a 21-Gauge Internally Cooled Electrode: Ex Vivo and In Vivo Evaluation by Rat Liver
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使用 21 号内冷电极进行射频消融：通过大鼠肝脏进行体外和体内评估
DOI：
10.1007/s00270-020-02660-w
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发表时间：
2020
影响因子：
2.9
通讯作者：
Yamakado Koichiro
中科院分区：
文献类型：
--
作者：
Takaki Haruyuki;Kodama Yuki;Miyamoto Hisao;Iijima Yuto;Kikuchi Yoshinari;Kodama Hiroshi;Ueshima Eisuke;Nakasho Keiji;Wada Reona;Yamakado Koichiro
目的评价21规(G)内冷射频（RF）电极在离体和离体大鼠肝脏中的凝固性能。材料与方法研制了一种21-G内冷单极射频电极原型，有效电极尖端长度为5.0 mm。在离体和体内大鼠肝脏中对该电极形成的烧蚀区大小进行了评价。5种RF功率（3w、5w、7w、9w和11w）分别施加在电极内冷冻水循环和不循环的情况下。比较了烧蚀区的大小。在射频消融后24小时和7天对消融区进行组织病理学评估。结果体外实验发现，在冷冻水循环中施加射频能量可显著增加消融体积。体内实验结果表明，射频功率为7 W时，烧蚀体积达到最大值（532.3±110.3 mm3）。组织病理学检查显示射频消融后24小时出现凝固性坏死，明确了消融区边界。射频消融后7天也观察到纤维化改变。结论21径电极射频消融术可引起大鼠肝脏凝固性坏死。当射频功率为7 W，外加冷冻水循环时，烧蚀体积最大。
PurposeTo evaluate the coagulative performance of a 21-gauge (G) internally cooled radiofrequency (RF) electrode using ex vivo and in vivo rat liver.Materials and MethodsWe developed a prototype of 21-G internally cooled monopolar RF electrode with 5.0 mm active tip length. The ablative zone size created by this electrode was evaluated in ex vivo and in vivo rat liver. Five RF powers (3 W, 5 W, 7 W, 9 W, and 11 W) were applied with and without circulation of chilled water within the electrode. The ablation zone sizes were compared. Histopathological evaluation of the ablation zone was also performed at 24 h and at 7 days after RF ablation.ResultsFrom ex vivo experiments, the ablation volume was found to increase significantly when RF energy was applied with the chilled water circulation. Results of in vivo experiments demonstrate that the ablation volume reached its maximum value when RF power of 7 W was applied (532.3 ± 110.3 mm3). Histopathological examination showed delineated coagulation necrosis at 24 h after RF ablation, which clarified the ablation zone border. Fibrotic change was also observed at 7 days after RF ablation.ConclusionRF ablation using a 21-gauge electrode produced coagulation necrosis in the rat liver. The ablation volume became maximum when RF power of 7 W was applied with chilled water circulation.
影响因子：
6
作者：
Cui S;Heller HT;Waikar SS;McMahon GM
通讯作者：
McMahon GM