IkB kinase epsilon expression in adipocytes is upregulated by interaction with macrophages.
IkB kinase epsilon expression in adipocytes is upregulated by interaction with macrophages.
复制标题
脂肪细胞中 IkB 激酶 epsilon 的表达通过与巨噬细胞的相互作用而上调。
DOI：
10.1080/09168451.2014.925776
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Yanaka N.
中科院分区：
文献类型：
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作者：
Sanada Y;Kumoto T;Suehiro H;Yamamoto T;Nishimura F;Kato N;Yanaka N.
脂肪组织中的巨噬细胞浸润以及与脂肪细胞的相互作用被充分证明参与脂肪炎症和肥胖相关并发症。在这项研究中，我们分离了IκB激酶ε（IKKε），它是一种关键的脂肪细胞因子，在体内与脂肪组织中的巨噬细胞相互作用可能受到影响。我们发现，在遗传性肥胖和饮食诱导的肥胖小鼠中，白色脂肪组织中IKK εmRNA表达水平均升高。此外，给予维生素B6（一种抗炎维生素）可降低IKKεmRNA的表达，并且脂肪组织中IKK ε的表达水平与浸润的巨噬细胞数量密切相关。在共培养系统中，我们发现IKK ε在脂肪细胞中的表达通过与活化的巨噬细胞的相互作用而上调。这项研究为IKKε提供了新的见解，IKK ε在肥胖发展过程中参与脂肪组织炎症。
Macrophage infiltration in the adipose tissue, and the interaction with adipocytes, is well documented to be involved in fat inflammation and obesity-associated complications. In this study, we isolated IκB kinase ε (IKKε) as a key adipocyte factor that is potentially affected by interaction with macrophages in adipose tissuein vivo. We showed thatIKKεmRNA expression levels in white adipose tissue were increased in both genetic and diet-induced obese mouse. Furthermore,IKKεmRNA expression was decreased by the administration of vitamin B6, an anti-inflammatory vitamin, and thatIKKεexpression levels in adipose tissue were closely correlated with the numbers of infiltrating macrophages. In a co-culture system, we showed thatIKKεexpression in adipocytes was upregulated by interaction with activated macrophages. This study provides novel insight into IKKε, which is involved in adipose tissue inflammation during the development of obesity.