Low-level environmental lead exposure in childhood and adult intellectual function: a follow-up study.
Low-level environmental lead exposure in childhood and adult intellectual function: a follow-up study.
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DOI：
10.1186/1476-069x-10-24
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发表时间：
2011-03-30
期刊：
影响因子：
--
通讯作者：
Needleman HL
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文献类型：
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作者：
Mazumdar M;Bellinger DC;Gregas M;Abanilla K;Bacic J;Needleman HL
早期铅暴露可能是成年期神经认知功能损害的危险因素。我们试图评估早期生活环境铅暴露与成年后智力功能之间的关系。我们还试图确定哪个时间段的血铅浓度最能预测成人的结局。我们招募了波士顿地区的成年人，他们在新生儿和幼儿时参加了一项前瞻性队列研究，研究了铅暴露与儿童智力功能之间的关系。智商是用韦氏简明智力量表（WASI）测量的。铅浓度和智商分数之间的关联进行了检查，使用线性回归。43名成年人参加了神经心理学测试。儿童期血铅浓度（4岁和10岁时血铅浓度的平均值）与全面智商的关系最密切（β = -1.89 ± 0.70，p = 0.01）。在6个月（β = -1.66 ± 0.75，p = 0.03）、4岁（β = -0.90 ± 0.41，p = 0.03）和10岁（β = -1.95 ± 0.80，p = 0.02）时，全量表智商也与血铅浓度显著相关。调整母亲的智商改变了回归系数的显著性。我们的研究表明，儿童时期的铅暴露可以预测成年后的智力功能。我们的研究结果还表明，学龄期铅暴露可能代表一个时期的易感性增加。然而，由于样本量小，不能排除母亲智商的潜在混杂效应，应该在更大的研究中进行评估。
Early life lead exposure might be a risk factor for neurocognitive impairment in adulthood. We sought to assess the relationship between early life environmental lead exposure and intellectual function in adulthood. We also attempted to identify which time period blood-lead concentrations are most predictive of adult outcome. We recruited adults in the Boston area who had participated as newborns and young children in a prospective cohort study that examined the relationship between lead exposure and childhood intellectual function. IQ was measured using the Wechsler Abbreviated Scale of Intelligence (WASI). The association between lead concentrations and IQ scores was examined using linear regression. Forty-three adults participated in neuropsychological testing. Childhood blood-lead concentration (mean of the blood-lead concentrations at ages 4 and 10 years) had the strongest relationship with Full-Scale IQ (β = -1.89 ± 0.70, p = 0.01). Full-scale IQ was also significantly related to blood-lead concentration at age 6 months (β = -1.66 ± 0.75, p = 0.03), 4 years (β = -0.90 ± 0.41, p = 0.03) and 10 years (β = -1.95 ± 0.80, p = 0.02). Adjusting for maternal IQ altered the significance of the regression coefficient. Our study suggests that lead exposure in childhood predicts intellectual functioning in young adulthood. Our results also suggest that school-age lead exposure may represent a period of increased susceptibility. Given the small sample size, however, the potentially confounding effects of maternal IQ cannot be excluded and should be evaluated in a larger study.