Bayesian adaptive biased-coin designs for clinical trials with normal responses
Bayesian adaptive biased-coin designs for clinical trials with normal responses
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DOI：
10.1111/j.0006-341x.2005.031002.x
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发表时间：
2005-03-01
期刊：
影响因子：
1.9
通讯作者：
Biswas, A
中科院分区：
文献类型：
--
作者：
Atkinson, AC;Biswas, A
适应性设计用于III期临床试验，以使分配模式向更好的治疗倾斜。我们使用最优设计理论推导出一个有连续反应的序贯设计的偏态贝叶斯有偏硬币过程。偏斜设计用于提供自适应设计，其性能进行了数值和理论研究。重要的属性是损失和分配的比例，以更好的治疗。
Adaptive designs are used in phase III clinical trials for skewing the allocation pattern toward the better treatments. We use optimum design theory to derive a skewed Bayesian biased-coin procedure for sequential designs with continuous responses. The skewed designs are used to provide adaptive designs, the performance of which is studied numerically and theoretically. Important properties are loss and the proportion of allocation to the better treatment.