Transforming growth factor β can mediate apoptosis via the expression of TRAIL in human hepatoma cells
Transforming growth factor β can mediate apoptosis via the expression of TRAIL in human hepatoma cells
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DOI：
10.1002/hep.20757
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发表时间：
2005-07-01
期刊：
影响因子：
13.5
通讯作者：
Walczak, H
中科院分区：
文献类型：
--
作者：
Herzer, K;Ganten, TM;Walczak, H
Transforming growth factor beta (TGF-beta) has been shown to induce apoptotic cell death in normal and transformed hepatocytes. However, the exact mechanism through which TGF-beta induces cell death is still unknown. We examined a potential role of various death receptor/ ligand systems in TGF-beta-induced apoptosis and identified the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a mediator of TGF-beta-induced apoptosis in hepatoma cells. TGF-beta-induced apoptosis is significantly impaired upon blockage of TRAIL. We show that TRAIL is upregulated in hepatoma cells upon treatment with TGF-beta, whereas TRAIL receptor levels remain unchanged. In conclusion, our results provide evidence that the TRAIL system is critically involved in TGF-beta-induced cell death in liver pathology.
