Relationship between fetal weight, placental growth and litter size in mice from mid- to late-gestation
Relationship between fetal weight, placental growth and litter size in mice from mid- to late-gestation
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DOI：
10.1016/j.reprotox.2005.08.002
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发表时间：
2006-04-01
影响因子：
3.3
通讯作者：
Yokoyama, K
中科院分区：
文献类型：
--
作者：
Ishikawa, H;Seki, R;Yokoyama, K
在哺乳动物中，胎盘由母体和胎儿组成，在胎儿发育中很重要，因为它为胎儿提供所需的营养。我们研究了从妊娠中期到晚期胎盘生长和窝仔数对小鼠胎儿体重的影响。孕13.5天雄性胎儿的平均体重大于雌性。在妊娠中期，胎儿重量与胎盘重量之间存在显著相关性（P < 0.05），但在妊娠晚期，两者之间无相关性。17.5dpc时，公母仔的窝仔数与胎仔体重呈显著正相关（P < 0.05）。这些结果表明，胎儿体重在妊娠中期由胎盘生长调节，而胎仔数的影响在妊娠后期更为突出。(c)2005年爱思唯尔公司All rights reserved.
In mammals, the placenta, which consists of maternal and fetal components, is important in fetal development because it supplies the fetus with the nourishment it needs. We investigated the effects of placental growth and litter size on mouse fetal weights from mid- to late-gestation. The mean weight of male fetuses at 13.5 days post coitum (dpc) was larger than that of females. Although there was a significant correlation between fetal and placental weights in both males and females during mid-,gestation (P < 0.05), there was no correlation during late-gestation. However, a significant correlation was observed between litter size and fetal weights in both males and females at 17.5 dpc (P < 0.05). These findings suggest that fetal weight is regulated by placental growth during mid-gestation, while the effects of litter size are more prominent towards late-gestation. (c) 2005 Elsevier Inc. All rights reserved.