Ubiquitination and Degradation of the Inhibitors of NF-κB
Ubiquitination and Degradation of the Inhibitors of NF-κB
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DOI：
10.1101/cshperspect.a000166
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发表时间：
2010-02-01
影响因子：
7.2
通讯作者：
Ben-Neriah, Yinon
中科院分区：
文献类型：
--
作者：
Kanarek, Naama;London, Nir;Ben-Neriah, Yinon
NF-κ B活化的关键步骤是NF-κ B二聚体从其抑制性蛋白质中释放，通过I κ B的蛋白水解实现。这个不可逆的信号步骤构成了转录激活的承诺。该信号最终通过NF-κ B的核排出而终止，这是基于NF-κ B的I κ B α转录、合成和I κ B α依赖性核输出的负反馈环的结果（Karin and Ben-Neriah 2000）。本文通过比较几种I kappa B的降解情况和讨论I kappa B泛素化机制的特点，综述了信号诱导I kappa B泛素化和降解的过程。
The key step in NF-kappa B activation is the release of the NF-kappa B dimers from their inhibitory proteins, achieved via proteolysis of the I kappa Bs. This irreversible signaling step constitutes a commitment to transcriptional activation. The signal is eventually terminated through nuclear expulsion of NF-kappa B, the outcome of a negative feedback loop based on I kappa B alpha transcription, synthesis, and I kappa B alpha-dependent nuclear export of NF-kappa B (Karin and Ben-Neriah 2000). Here, we review the process of signal-induced I kappa B ubiquitination and degradation by comparing the degradation of several I kappa Bs and discussing the characteristics of I kappa Bs' ubiquitin machinery.